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About reducing integro-differential equations with infinite limits of integration to systems of ordinary differential equations
Advances in Difference Equations volume 2013, Article number: 187 (2013)
The purpose of this paper is to propose a method for studying integro-differential equations with infinite limits of integration. The main idea of this method is to reduce integro-differential equations to auxiliary systems of ordinary differential equations.
Results: a scheme of the reduction of integro-differential equations with infinite limits of integration to these auxiliary systems is described and a formula for representation of bounded solutions, based on fundamental matrices of these systems, is obtained.
Conclusion: methods proposed in this paper could be a basis for the Floquet theory and studies of stability, bifurcations, parametric resonance and various boundary value problems. As examples, models of tumor-immune system interaction, hematopoiesis and plankton-nutrient interaction are considered.
MSC:45J05, 45J15, 34A12, 34K05, 34K30, 47G20.
Integro-differential equations appeared very naturally in various applications (see, for example, [1–5]), which explains the interest in the theory of these equations (see, for example, [6, 7]). Various examples, in which the simple enough integro-differential equation
by elementary operations can be reduced to a system of ordinary differential equations, are known. In this connection, let us refer, for example, to the monograph . Note the idea of the chain trick used in various applications (see, for example, [9, 10]) and its developed form in the paper . Independently, the idea of a reduction to systems of ordinary differential equations in the study of stability, which was, actually, the chain trick, was presented in . Starting with this reduction, approaches to the study of stability and bifurcation of integro-differential equations were proposed in the papers [13–16]. The approach developed in these papers allowed researchers to define a notion of periodic integro-differential systems and to build the Floquet theory for integro-differential equations on this basis in . The first known results on estimates of distance between two adjacent zeros of oscillating solutions to a linearization of equation (1.1) and results connecting oscillation behavior and the exponential stability were obtained on this basis . A parametric resonance in linear almost periodic systems was studied in , and the bifurcation of steady resonance modes for integro-differential systems was investigated in . Stabilization by control in a form of integrals of solutions was studied in . The stability of partial functional differential equations on the basis of this reduction was studied in . Constructive approach to a phase transition model was presented in . A reduction to infinite dimensional systems was considered in [21, 23, 24]. In all these papers the limits of integration in integral terms were 0 and t, and this was very essential.
The main goal of this paper is to present a method reducing integro differential equations with infinite limits of integration
to systems of ordinary differential equations. In a future we are planning to develop the ideas of noted above papers for equation (1.2). As well as we know, there are no results of this type. Important motivation in the study of integro-differential equation (1.2) can be found also in various applications of such equations in, for example, models of tumor-immune system interaction , hematopoiesis , stability and persistence in plankton models  which will be considered below.
Using these notations, we can write
It is possible to represent the vector in the form , where , . In many applications, system (1.4) can be represented in the form
The first equation in (1.7) depends on its integral part v on delay only (see (1.4)) and the second one is dependent on advance only. Note that the cases and can be also considered. If , we get a system with distributed delay, and if , the one with distributed advance. Note that a combination of distributed and concentrated deviations is also possible. Considering such systems, we do not discuss questions of existence of solutions and assume that solutions to these systems exist. Note that even for the Volterra equation, one-point problem (1.1) with the condition , , can have more than one solution or not have solutions at all (see, for example, , Chapter 1, Section 9, pp. 70-74).
For system (1.2) our method essentially uses the properties of linear nonhomogeneous systems of ODEs, possessing exponential dichotomy  or hyperbolicity . It is known that such systems have (under corresponding conditions) unique bounded on the axis solution. Corresponding bibliography can be found in . The case of autonomous systems was considered in [29, 30]. Below, in the next paragraph, we formulate, in convenient for us form, a result about the existence and structure of the solution for general non-autonomous linear systems of ODEs. This result is based on the theorem about reduction of hyperbolic systems to a block diagonal form .
2 Methods: about bounded solutions of linear nonhomogeneous systems
and the corresponding homogeneous system
where , P is an matrix and g is an n-vector function with continuous bounded elements.
We use the following definition introduced in .
Definition 2.1 We say that system (2.2) is hyperbolic if there exist constants and and hyperplanes and , such that if for , , then the solution satisfies the inequality
and if , the inequality
Theorem 2.1 
Let system (2.2) be hyperbolic. Then there exists an matrix with bounded elements such that its inverse matrix also possesses bounded elements and the transform reduces system (2.2) to the form
where , , .
If we denote , where is a fundamental matrix of the first system in (2.5), , where is a fundamental matrix of the second system in (2.5), such that , , , , then
We present corresponding constructions, developed in  for the proof of this theorem, which will be used below in our paper.
be a fundamental matrix of system (2.2), where () are linearly independent solutions of system (2.2), , . Setting , , we define, for , the vectors
For , we set , , and for , we define corresponding vectors according to scheme (2.9). The matrix
is bounded with its inverse matrix and . The vectors are pairwise orthogonal and , . Let us set
It is clear from the construction of the matrix that is a block diagonal
Setting in (2.2) , we get
where . It follows from (2.12) and (2.13) that , where , . Thus system (2.13) has the form
Define the Cauchy matrices and such that , , where is a unit -matrix.
Let us prove the following assertion about the representation of bounded solutions to system (2.1).
Theorem 2.2 Let all elements of and in system (2.1) be continuous and bounded for , and let system (2.2) be hyperbolic. Then system (2.1) has a unique bounded solution and this solution can be represented in the form
Proof Let us substitute
into system (2.1), then we get the system
for which the homogeneous system is of the form (2.13), (2.14).
Consider the matrix (2.16). It follows from the properties of the matrices , that equality (2.17) is fulfilled. It follows from hyperbolicity of system (2.14) that
It follows from (2.16) and (2.20) that the integral in (2.15) converges for bounded functions every t. Computing the derivative of Green’s matrix, we get
Let us verify now that formula (2.15) defines the solution of equation (2.19). Representing in the form
differentiating it and taking into account (2.21) and (2.17), we get
The obtained solution is unique. If we assume the existence of two bounded solutions and , then is a bounded on the axis solution of (2.2). From hyperbolicity, it follows that it is a zero solution. □
Corollary 2.1 If homogeneous system (2.2) is hyperbolic and (), then nonhomogeneous system (2.1) has a unique bounded for solution, and this solution can be represented in the following form:
where , is a fundamental matrix of system (2.2).
Remark 2.1 If the matrix in (2.1) is a constant one, analogous results are obtained in [29, 30]. The existence of a unique bounded solution under the assumption of the exponential dichotomy on for system (2.2) with bounded variable coefficients is known (see, , p.69, Proposition 2). Similar topics were also studied in .
3 Results: about reduction of integro-differential equations to systems of ordinary differential equations
3.1 Reduction to the system of first-order ordinary differential equations
Consider the system
where the kernel is of the form
Series in (3.2) can be, for example, corresponding orthogonal expansions, series of exponents. One of the interesting cases is a finite sum in (3.2). We assume that all the matrices are differentiable and invertible. We can write
Define the so-called multiplicative derivative 
is the Cauchy matrix of the system
Let us set
If the matrix , defined by (3.5), satisfies the inequality
(this is the analog of (2.6)) for , then in formula (3.7), according to Corollary 2.1, can be considered as a solution of the one-point problem
if we consider as a known function bounded on . Adding to equation (3.8) the so-called initial function (continuous and bounded on )
we can consider representation (3.7) as a substitution, which leads us to the one-point problem
where was defined above.
We have proven the following assertion.
Theorem 3.1 Let
matrices in the kernels (3.2) be continuously differentiable and invertible for , ,
systems (3.6) be of dimension , where
be hyperbolic for every j in the sense of Definition 2.1 (for ).
Then the bounded solution of system (3.1) with the kernel of the form (3.2) and the initial function (3.9) and the first component of the solution to the countable system
where , , ,
Remark 3.1 If (3.2) is a finite sum, then system (3.11) is finite dimensional.
Remark 3.2 The system of the form
can be found in various applications. It can be reduced by the change of variable to system (3.1) with the kernel .
Remark 3.3 System (3.11) can be used for studying qualitative properties and for an approximate solution of system (3.1) of integro-differential system (3.1). An important basis is the theory of countable systems [33–37]; see also the papers [24, 38–41].
Remark 3.4 Analogous result could be obtained for the system
in Section 5.
3.2 Reduction to the system of ordinary differential equations of high orders
Consider the nonhomogeneous linear equation of n th order
and the corresponding homogeneous equation
where all coefficients () and f are essentially bounded on .
be a fundamental system of solutions of equation (3.14). Using (3.15), we can construct the solution such that
assuming that the integral converges. Let us verify that (3.17) is a solution of (3.13). Actually,
for , and
It follows from (3.18), (3.19) and the equality that
The obtained particular solution satisfies the initial conditions
Example 3.1 For the equation
Example 3.2 For the equation
Consider the system
where , , , and assume that
where () are the Cauchy functions of corresponding linear equations
where φ is considered as a known function. Assuming that the Cauchy functions imply convergence of integrals (3.29) for all j and that the function φ is bounded, we obtained that system (3.26) is reduced to the countable system
in the sense that the solution of (3.26) coincides with the component x of the solution vector of (3.31).
4 Results: examples of reduction of integro-differential equations to systems of ordinary differential equations
Example 4.1 Model of tumor-immune system 
This system is an example of two-dimensional system (3.26) with distributed delay of x. In  the following kernel
is used and the case is studied in detail. It is clear from Example 3.1 (see (3.24) and (3.25)) that the substitution
reduces system (4.1) with the kernel (4.2) to the system of ordinary differential equations
which can be written as a system of the order . Note that for , the last equation in system (4.4) is of the form .
Example 4.2 Model of hematopoiesis . This model can be written in the form
The coefficients α, β and δ in (4.5) are positive ω-periodic functions, the kernel K satisfies the condition . The change of variable and then the substitution of the type (4.3) in the case of the kernel (4.2) reduces integro-differential equation (4.5) to the system of ordinary differential equations
Consider now the case of both distributed and concentrated delays in the system
Let us describe the process of reduction, which is similar to the process described in the Section 3.1. The vector x is of the form . Denoting
we make the substitution (compare with (3.7))
Introduce the initial functions
Under the assumption of convergence of the integrals, substitution (4.8) reduces (4.7) to the system
with the initial conditions defined by (4.10).
Example 4.3 The model of the plankton-nutrient interaction 
The initial functions
The description of all parameters can be found in the paper . is a known function. Concerning the function , it is assumed that
A particular case of is
Concerning the kernel, it is assumed that is a bounded nonnegative function such that .
In  the properties of system (4.12) are considered in various particular cases of the kernel . The most general of them is the following:
It is clear from (4.2) for that
The substitution (4.3) for is of the form
and it reduces system (4.12) to the system
5 Results: systems with advanced argument
Using results of Section 2 and approach of Section 3 (Section 3.1), we describe reduction of the integro-differential system
and the kernel
to a system of ordinary differential equations. Introducing the matrix and the equation
by the formulas (3.3), (3.4) and (3.5), let us require that () satisfy inequalities (2.6) under the assumption that in the condition of hyperbolicity.
Introduce the substitution
According to Corollary 2.1, we can consider (5.3) for as the solution of the one-point problem for system (3.8), supposing is a known function
As a result, we obtain an analog of Theorem 3.1 for equation (5.1) with the kernel (5.2).
Theorem 5.1 Let
matrices in the kernels (5.2) be continuously differentiable and invertible for , ,
systems (3.6) be of dimension , where
be hyperbolic for every j in the sense of Definition 2.1 (for ).
Then the bounded solution of system (5.1) with the kernel of the form (5.2) and the end function (5.4) and the first component of the solution to the system
where , , ,
6 Results: about systems with both delayed and advanced argument
Let us consider system (1.2) with distributed delay and advance. Denote in such a form that system (1.2) can be written in the form
Using the technique of Sections 3 and 5, we introduce
where , , and denote , , , .
Requiring satisfies inequality (2.6), the first for and the second for , we obtain that solution of system (6.1) satisfies also the following problem:
The method described above allows us to reduce systems of integro-differential systems with distributed delay and/or advance to systems of ordinary differential equations. For Volterra systems of the type (1.1), it was a basis for studying stability, bifurcation, Floquet theory, parametric resonance, stabilization and oscillation properties for integro-differential equations with ordinary [13–18, 20] and partial [21, 22] derivatives. We could extend the main results of these works to integro-differential equation (1.2).
Generally speaking, after the reduction, we get infinity dimensional systems of ordinary differential equations. For their analysis, the theory of countable differentiable systems could be used [33–37].
In the study of various biological systems, the linear chain trick method was used (see, for example, [9, 10]). It is clear (see Section 4) that our approach includes the linear trick method. Note also the use of W-transform, which also allows researchers to reduce integro-differential equations to systems of ordinary differential equations .
The proposed method allows us also to study generalized and impulsive systems. For example, in the case of discontinuous solutions described by Heaviside functions , we can use its connection with δ-function: and to get to a system of integro-differential equations. Introducing the sequence, for example,
where , we can consider the obtained system of integro-differential equations as an approximation of generalized equations. This allows us in corresponding cases to reduce the study of a generalized and impulsive system to the analysis of the sequence of integro-differential equations, and consequently to the analysis of the corresponding sequence of systems of ordinary differential equations.
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Authors thank the reviewers for their reports, which have essentially improved the paper.
There are no competing interests.
Results are obtained by both authors as a result of their many years of collaboration. All authors read and approved the final manuscript.