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Figure 8 | Advances in Difference Equations

Figure 8

From: Modeling bacterial resistance to antibiotics: bacterial conjugation and drug effects

Figure 8

Characteristic of resistant bacteria. Three different characteristics of bacteria by fixing the resistance acquisition number equaling 3 are considered: (1) strain with less likelihood of losing a plasmid and horizontally transferring a plasmid \(p = 0.1, \lambda = 0.65\) (red line), (2) strain with intermediate likelihood of loosing a plasmid and horizontally transferring a plasmid \(p = 0.5, \lambda = 1.05\) (cyan line), and (3) strain with more likelihood of losing a plasmid and horizontally transferring a plasmid \(p = 0.9, \lambda = 1.45\)—purple line. (a) Prevalence of sensitive and resistant bacteria when the antibiotic M is administered only (solid line) and when the antibiotic N is administered only (dashed line). (b) Prevalence of sensitive and resistant bacteria for the one-dose antibiotic switching of M and N. (c) & (d) Prevalence of sensitive and resistant bacteria for two-dose antibiotic switching of M and N starting with M and N, respectively. (e) Prevalence of sensitive and resistant bacteria with two doses of M and three doses of N. (f) Prevalence of sensitive and resistant bacteria with two doses of N and three doses of M. (\(S(0) = 1.2 \times 10^{8}\) and \(R(0) = 2.3 \times 10^{8}\))

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