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Figure 7 | Advances in Difference Equations

Figure 7

From: Modeling bacterial resistance to antibiotics: bacterial conjugation and drug effects

Figure 7

Switching of antibiotic agents. (a) Prevalence of sensitive and resistant bacteria with exposure to the antibiotic M: without and with introduction of the antibiotic N (dashed line for administration of the antibiotic M only and solid line for administration of three doses of the antibiotic M followed by three doses of the antibiotic N. (b) & (c) Prevalence of sensitive and resistant bacteria with administration of two doses of the antibiotic M and four doses of the antibiotic N and with administration of one dose of the antibiotic M and four doses of the antibiotic N, respectively. (d) Prevalence of sensitive and resistant bacteria with exposure to the antibiotic N: without and with introduction of the antibiotic M (dashed line for administration of the antibiotic N only and solid line for administration of three doses of the antibiotic N followed by three doses of the antibiotic M. (e) & (f) Prevalence of sensitive and resistant bacteria with administration of two doses of the antibiotic N and four doses of the antibiotic M and with administration of one dose of the antibiotic N and four doses of the antibiotic M, respectively. (g) Prevalence of sensitive and resistant bacteria according to antibiotic switching between M and N starting with M (solid line) and N (dashed line). (h) Prevalence of sensitive and resistant bacteria switched between two doses of M and two doses of N starting with with M (solid line) and N (dashed line). (\(S(0) = 1.2 \times 10^{8}\) and \(R(0) = 2.3 \times 10^{8}\))

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