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Figure 5 | Advances in Difference Equations

Figure 5

From: Modeling bacterial resistance to antibiotics: bacterial conjugation and drug effects

Figure 5

Investigation of antibiotic regimens after resistant bacteria are prevalent. Two types of antibiotics are considered: drug M that kills only sensitive bacteria and drug N that kills both sensitive and resistant bacteria. (a) Antibiotic concentration profile when the elimination rate varies (\(\alpha = 0.075\)—solid line, \(\alpha = 0.15\)—dash line, and \(\alpha = 0.225\)—dot line). (b) & (c) Prevalence of sensitive and resistant bacteria according to the elimination rate when drug M and N are administered, respectively. (d) Two concentration profiles when two drug regimens are considered with the same total dose: every 12 hours and every 24 hours. (e) & (f) Prevalence of sensitive and resistant bacteria according to two drug regimens when drug M and N are given, respectively (\(S(0) = 1.2 \times 10^{8}\) and \(R(0) = 2.3 \times 10^{8}\))

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