Modeling dynamics of cancer virotherapy with immune response

Advances in Continuous and Discrete Models

Theory and Modern Applications

Table 1 The model parameters, their description and values

Parameter	Description	Value	Units	Reference
λ	Tumor growth rate	2 × 10⁻²	1/h	[24]
d	Death rate of uninfected tumor cells	0.0071	1/h	[25]
β	Infection rate of the virus	7/10 × 10⁻⁹	mm³/h virus	[24]
δ	Death rate of infected tumor cells	1/18	1/h	[24]
b	Burst size of free virus	50	viruses/cell	[24]
γ	Clearance rate of the virus	0.0119	1/h	[26]
α	Immune killing rate of uninfected tumor cells	2 × 10⁻⁸	mm³/h immune cell	estimated
μ	Immune killing rate of infected tumor cells	2 × 10⁻⁸	mm³/h immune cell	[24]
k	Immune killing rate of the virus	10⁻⁸	mm³/h immune cell	[24]
\(s_{1}\)	Stimulation rate of the immune response by infected cells	5.6 × 10⁻⁷	mm³/h infected cell	[24]
\(s_{2}\)	Stimulation rate of the immune response by uninfected cells	5.6 × 10⁻⁷	mm³/h uninfected cell	estimated
ρ	Clearance rate of the immune response	0.002	1/h	[10]