Theory and Modern Applications
Table 3 Model parameter values in Models C(i), (ii), and (iii) for \(t \in[0, 6]\)
Model | Parameter | Description | Value |
|---|---|---|---|
Model C(i) | \(c_{0}\) | Initial concentration of drug dosage | 500 units |
\(k_{1}\) | Rate constant of drug in GI tract | 0.9776 hour−1 | |
\(k_{c}\) | Clearance constant | 0.2213 hour−1 | |
λ | Eigenvalues | −0.7448, −0.9776 | |
Model C(ii) | \(c_{0}\) | Initial concentration of drug dosage | 500 units |
\(k_{b}\) | Rate constant of drug in bloodstream | 0.9776 hour−1 | |
\(k_{t}\) | Rate constant of drug in tissue medium | 0.3293 hour−1 | |
\(k_{c}\) | Clearance constant | 0.2213 hour−1 | |
λ | Eigenvalues | −0.0492, −1.4789 | |
Model C(iii) | \(c_{0}\) | Initial concentration of drug dosage | 500 units |
\(k_{ab}\) | Rate constant of drug in arterial blood | 0.9776 hour−1 | |
\(k_{t}\) | Rate constant of drug in tissue medium | 0.3293 hour−1 | |
\(k_{c}\) | Clearance constant | 0.2213 hour−1 | |
λ | Eigenvalues | −0.2213, −0.3293, −0.9776 |