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Advances in Continuous and Discrete Models

Theory and Modern Applications

Figure 1 | Advances in Difference Equations

Figure 1

From: Theoretical analysis of the delay on the p53 micronetwork

Figure 1

Schematic depiction of the model. p53 promotes the transcription of MDM2, which in turn inhibits p53 through ubiquitination, forming a negative feedback loop of p53-MDM2; Activated ATM promotes the stability and activation of p53, which in turn inactivates ATM, forming a negative feedback loop of p53-ATM. The promotion and inhibition of state transition are separately denoted by arrow-headed solid lines and bar-headed lines, and τ indicates the delay of p53 on promoting Mdm2 or inhibiting ATM

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