Theory and Modern Applications
Table 1 The parameter values of the proposed model
From: Mathematical modeling of hepatitis B virus infection for antiviral therapy using LHAM
Parameter | Description | Range | Unit |
|---|---|---|---|
α | Hepatocytes production rate | 1 | Cell day−1 ml−1 |
\(d_{T}\) | Hepatocytes death rate | 0.01–9 × 10−4 | day−1 |
φ | Infectivity rate | 1 × 10−10–6.6 × 10−8 | ml virions−1 day−1 |
δ | Death rate of infected hepatocytes | 0.06–0.25 | day−1 |
a | Return to uninfected cell rate | 0.17 | Cell day−1 ml−1 |
b | Infected cells killing rate by CTL response | 51.02–58.9 | Cell day−1 ml−1 |
r | Virus production rate | 1.4–164 | Virions cell−1 day−1 |
c | Decay rate | −0.7–43.8 | Cell day−1 ml−1 |
s | CTL stimulation rate | 0.4 | day−1 |
ε | Viral load | 3 × 10−4 | ml |
σ | Rate of antigenic stimulation in decay absence | 1.7 × 108 | cells day−1 |
ρ | export of precursor CTL cells | 427.1 | cells |