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Hostpathogen interaction for larvae oysters with salinity dependent transmission
Advances in Difference Equations volume 2019, Article number: 409 (2019)
Abstract
Mathematical models of hostpathogen interactions are proposed and analyzed. Here hosts are oyster population in a freeswimming larval stage and assumably live in the closed homogeneous environment. In terms of an epidemic, they are classified into two states, namely susceptible and infectious hosts. The epidemic model of oyster hosts with seasonal forced transmission is firstly described by the SIS model where the region of attraction, the existence of equilibrium points, their stability conditions, and upper and lower bounds on the attack rate are investigated. Then freeliving pathogen is introduced in the oyster area. Numerical simulations are finally carried out by making use of the various salinitydependent transmissions in support of the hypothesis that the lower the salinity level, the lower oyster’s immunity.
Introduction
Like other organisms, oysters require energy to maintain their structure and maturity. They develop through various stages in their life cycle as shown in Fig. 1. The adult oysters produce eggs or sperms before releasing them to fertilize in the water column in the proper environment. The fertilized eggs drift along the current and develop into freeswimming larvae, the socalled presettlement oyster. After 2–3 weeks, they start to attach to a suitable hard substance, such as rock or shell. They are known as spat and become adult oysters in 1–3 years [1].
There are a variety of approaches to understand a result of changing environmental conditions, population dynamics, and a combination of both. The Princeton Ocean Model (POM) is widely used to simulate marine circulation [2], and the dynamic energy budget model (DEB) is developed for mechanistic studies [3,4,5,6]. Using DEB model, the authors in [7,8,9] explored the relationship between environmental variables and bivalve sustainability.
Mortality of bivalve species living in variable environmental conditions has been widely studied due to their ecological and economic importance. Water runoff from the heavy rain is considered a major cause of death in the oyster culture area, whereas salinity range for oyster growth and development is about 10–25 ppt. After exposure to salinity changes, oysters require more energy to maintain their internal salinity concentration at a desired level. Lavaud et al. [10] proposed that salinity maintenance may be extracted from structure maintenance. However, Fuhrmann et al. [11] proposed that the increasing energetic demand may divert resources from defense mechanisms against pathogens, which is a process of maturity maintenance [3]. Another significant cause of mortality of larval oysters was reported as a pathogen. Common pathogens of oyster include bacteria, viruses, and parasites. Two examples of oyster’s pathogen are Ostreid herpersvirus 1 (OsHV1) spotted in France from the abnormal mortality crisis of C. gigas oyster, especially spat and juvenile, and Perkinsus marinus, a parasite which causes Dermo disease. A variety of host–pathogen models have been proposed in the literature [12,13,14,15,16].
In this paper, we are interested in hostpathogen interactions in which the seasonal salinity is due to changes in transmission rate. Thus, we construct the mathematical model of presettlement oyster population with SIS model in Sect. 2. The seasonal salinity is assumed to affect oyster immune system with the hypothesis that the lower salinity, the higher infection rate. In the study case of Bandon Bay, Thailand, the salinity can be conferred to be a sinusoidal function over time [17]. Thus, the hosttohost disease transmission rate can be considered as a sinusoidal function or sinusoidal function with limitedvalue. In Sect. 3, the model is modified into SISP model by including freeliving pathogens. Thus environmenttohost transmission rate is also taken into account. In Sect. 4, the numerical simulations illustrate the result from each set of parameters. The upper and lower of attack rates are also calculated.
The seasonally forced SIS model
Model formulation of unforced SIS model
Here, we consider the interaction between the susceptible and infectious populations living in a closed homogeneous environment. In particular, we focus on a freeswimming larval oyster. Let \(S(t)\) and \(I(t)\) be the number of susceptible and infectious hosts at time t, respectively. \(S(t)+I(t)=N(t)\) is the varying population size. The transition rates are homogeneously mixing. From the conceptual diagram in Fig. 2, SIS model can be constructed by the following system of ordinary differential equations:
where \(S(0)>0\) and \(I(0)>0\). All parameters are described in Table 1.
Throughout this work, \(\mathbb{R}^{+}\) is the set of nonnegative real numbers, \(\mathbb{R}^{n}\) is the Euclidean nspace, and \(\mathbb{R} _{+}^{2}\) is the nonnegative quadrant. The validity of system (1) is guaranteed by its uniform boundedness which can be proved by the following lemma.
Lemma 2.1
is the region of attraction. Then all solutions of system (1) starting in \(\mathbb{R}_{+}^{2}\) are uniformly bounded.
It is straightforward to obtain \(\limsup_{t\rightarrow \infty } N(t) \leq \frac{\varLambda }{ \mu }\). In other words, this lemma implies that all solutions of system (1) in \(\mathbb{R}_{+}^{2}\) eventually enter the region \(\varGamma _{1}\).
We now discuss the existence of equilibrium points of system (1).
Lemma 2.2
System (1) has the following equilibrium points:

(a)
The diseasefree equilibrium point \(L_{0}(\frac{\varLambda }{\mu },0)\) always exists;

(b)
The endemic equilibrium point \(L_{1}(\frac{\varLambda }{\mu R_{0}},\frac{\varLambda }{\mu +m}(1\frac{1}{R _{0}}))\) exists if \(R_{0}>1\), where \(R_{0}=\frac{\varLambda \beta }{\mu (\alpha +\mu +m)}\).
The lemma is obtained by using a standard technique in mathematical modeling. Next, we examine the stability conditions.
Theorem 2.3
The equilibrium points of system (1) satisfy the stability conditions as follows.

(a)
The diseasefree equilibrium point \(L_{0}(\frac{\varLambda }{\mu },0)\) is asymptotically stable if \(R_{0}<1\) and unstable if \(R_{0}>1\).

(b)
The endemic equilibrium point \(L_{1}(\frac{\varLambda }{\mu R_{0}},\frac{\varLambda }{\mu +m}(1\frac{1}{R _{0}}))\) is locally asymptotically stable if \(R_{0}>1\), and unstable if \(R_{0}<1\).
The proof of the local asymptotic stability at an equilibrium point \((S^{*},I^{*})\) can be completed by checking the eigenvalues of the Jacobian matrix at the equilibrium point, written as
Lemma 2.4
System (1) has no closed orbit.
Proof
According to system (1), \(f_{1} := \varLambda \beta SI + \alpha I  \mu S \) and \(f_{2} :=\beta SI  \alpha I  \mu ImI \) are continuous differentiable functions. Then we choose \(\phi _{1} = \frac{1}{SI} \). Thus
neither changes sign nor is identically zero in the first quadrant. Hence system (1) has no closed orbit by Dulac’s criteria. □
Consequently, unforced oscillations do not exist. However, there is a change of stability at the bifurcation point \(\beta = \mu (\alpha + \mu +m)/\varLambda \). The bifurcation diagram is described in the next section.
Forcing term
In nature, environmental conditions including salinity level change seasonally. Thus, the seasonally forced SIS model should be considered. The approaches to studying a mathematical model with timevarying parameter are limited. Among them, the numerical simulations are the most popular. Following [18], we can analyze theoretically in terms of upper and lower bounds on attack rate.
Let \(\beta (t)\) be the seasonallydependent transmission rate:
where T is the seasonal period. The properties are
Attack rate
The attack rate in year n is defined by
where \(\beta (t) S(t)I(t)\) is the incidence of new infectious hosts. Under the assumption that there exists a globally stable periodic solution \(S_{p}(t)\), \(I_{p}(t)\) with a Tperiod where
all solutions converge to the periodic solutions. Consequently, the seasonal attack rate is given by
For the special case \(\beta (t)=\bar{\beta }\) when \(R_{0}= \frac{\varLambda \bar{\beta }}{\mu (\alpha +\mu +m)}>1\), system (1) has a globally stable equilibrium point as follows:
It leads to the attack rate at equilibrium
Next, we drop the subscript p and analyze the upper and lower bounds on the attack rate in terms of the parameters.
Lemma 2.5
For any Tperiodic solution \((S(t),I(t))\) of system (1), we have the upper bound
Proof
Assume \((S(t),I(t))\) is a Tperiodic solutions of system (1). Obviously,
Since \(S(t)>0\) and \(S(t) + I(t) \leq \frac{\varLambda }{\mu }\), we get
□
Lemma 2.6
If \((S(t),I(t))\) is a Tperiodic solution of system (1), then
where \(\bar{I}= \frac{1}{T}\int _{0}^{T} I(t) \,dt\).
Proof
Obviously,
Therefore, we get
where \(\bar{I}= \frac{1}{T}\int _{0}^{T} I(t) \,dt\). □
Lemma 2.7
If \((S(t),I(t))\) is a Tperiodic solution of system (1), then
Proof
Dividing both sides of \(I'(t)\) by \(I(t)\), we get
After integrating both sides over \([0,T]\), the lefthand side vanishes because of periodicity. Then the proof is complete. □
Theorem 2.8
For any Tperiodic solution \((S(t),I(t))\) of system (1), we have the following upper and lower bounds:
Proof
First, we define
In the nonseasonal case, \(\eta _{0}=\eta _{1}=0\). Using Lemma 2.7, we have
Therefore, \(\bar{S} \leq \frac{\alpha +\mu +m}{\bar{\beta }(1\eta _{0})} = \frac{ \varLambda }{\mu R_{0}}(\frac{1}{1\eta _{0}})\).
On the other hand,
Then \(\bar{S} \geq \frac{\alpha +\mu +m}{\bar{\beta }(1+\eta _{1})} = \frac{ \varLambda }{\mu R_{0}}(\frac{1}{1+\eta _{1}})\).
Next, using Lemma 2.6, we have
Then
Since \(A \geq 0\), more precise upper and lower bounds become
□
The seasonally forced SISP model
Model formulation of unforced SISP model
BaniYaghoub et al. [19] hypothesized the contaminated environment by diseasecausing germs as a transition, transitionreservoir, and reservoir, while our SISP scenario assumes that susceptible hosts can be infected by both infectious hosts and pathogen shed by infected host. Next we propose and analyze an extension of system (1), including freeliving pathogen (FLP) load at time t, \(P(t)\). The conceptual diagram is illustrated in Fig. 3. Then SISP model can be written as follows:
where \(S(0)>0\), \(I(0)>0\), and \(P(0)>0\). The additional parameters are defined in Table 2.
Additionally, throughout this work, \(\mathbb{R}_{+}^{3}\) is the nonnegative octant. The validity of system (2) is guaranteed by its uniform boundedness which can be proved by the following lemma.
Lemma 3.1
is the region of attraction. Then all solutions of system (2) starting in \(\mathbb{R}_{+}^{3}\) are uniformly bounded.
Proof
It is easy to prove that \(S+I \leq \frac{\varLambda }{\mu }\) since \(\frac{dS}{dt}+\frac{dI}{dt}\) from system (1) and system (2) are identical. As a consequence, the third equation of system (2) yields
Thus, there exists \(M>0\) such that \(\limsup_{t\to \infty } P(t) \leq M\). This lemma also implies that all solutions of system (2) in \(\mathbb{R}_{+}^{3}\) eventually enter the region \(\varGamma _{2}\). □
We now discuss the existence of equilibrium points of system (2).
Lemma 3.2
System (2) has the following equilibrium points:

(a)
The diseasefree equilibrium point \(L_{0}(\frac{\varLambda }{\mu },0,0)\) always exists;

(b)
The endemic equilibrium point \(L_{1} (\frac{1}{R^{P}_{0}} , \frac{\mu }{\mu + m} (\frac{\varLambda }{ \mu }  \frac{1}{R^{P}_{0}}), \frac{\mu (b+\epsilon m)}{\gamma ( \mu +m)} (\frac{\varLambda }{\mu }\frac{1}{R^{P}_{0}})) \) exists if \(R^{P}_{0}> \frac{\mu }{\varLambda }\), where \(R^{P}_{0}=\frac{\beta \gamma + \delta (b+\epsilon m)}{(\alpha +\mu +m) \gamma }\).
By straightforward calculation, this lemma can be proven easily. To prevent the negative solution of endemic equilibrium point, the condition \(R^{P}_{0}> \frac{\mu }{\varLambda }\) must be satisfied. Then we examine the local asymptotic stability at an equilibrium point.
Theorem 3.3
The equilibrium points of system (2) satisfy the stability conditions as follows:

(a)
The diseasefree equilibrium point \(L_{0}(\frac{\varLambda }{\mu },0,0)\) is asymptotically stable if \(R^{P}_{0}<\frac{\mu }{\varLambda }\) and unstable if \(R^{P}_{0}>\frac{\mu }{\varLambda }\).

(b)
The endemic equilibrium point \(L_{1} (\frac{1}{R^{P}_{0}} , \frac{\mu }{\mu + m} (\frac{\varLambda }{ \mu }  \frac{1}{R^{P}_{0}}), \frac{\mu (b+\epsilon m)}{\gamma ( \mu +m)} (\frac{\varLambda }{\mu }\frac{1}{R^{P}_{0}}))\) is locally asymptotically stable if \(R^{P}_{0}>\frac{\mu }{\varLambda }\), and unstable if \(R^{P}_{0}<\frac{\mu }{\varLambda }\).
This theorem is proven by using Jacobian matrix at the equilibrium point \((S^{*},I^{*},P^{*})\) of linearized system (2) and Routh–Hurwitz conditions [20].
Before examining the bifurcation of system (2), we consider the nonexistence of limit cycle behavior first.
Lemma 3.4
System (2) has no closed orbit.
This lemma is proven by following the method used in Lemma 2.4 with Dulac’s function \(\phi _{2} = 1/SIP\). Therefore, Hopf bifurcation cannot occur.
Next β and δ are chosen as bifurcation parameters. The bifurcation diagram of forced SISP model obtained numerically is shown in the numerical simulations section. Figure 4(a) illustrates an occurrence of local bifurcation after the values of β change. Solid line and dotted line indicate the stable and unstable solutions respectively. The diseasefree equilibrium is illustrated as a straight line \(S = \varLambda /\mu \), while a curved line represents the endemic equilibrium. At the bifurcation point \(\beta = \frac{\mu }{\varLambda }( \alpha + \mu + m)\frac{\delta }{\gamma }(b+\epsilon m)\), the diseasefree equilibrium point is no longer stable, whereas the stable endemic equilibrium point exists as transmission rate β is increased. The bifurcation diagram of system (1) is shown in Fig. 4(a) when \(\delta =0\).
Figure 4(b) shows the stability regions of \(\beta  \delta \) bifurcation diagram. As a conclusion, the lower transmission rates β and δ, the higher the number of susceptible host.
Forcing term
Next we consider the seasonally forced SISP model. \(\delta (t)\) is a new seasonallydependent transmission rate:
where T is the seasonal period, and the properties are
Attack rate
In addition to environmenttohost transmissions, the attack rate in year n becomes
Like SIS model, the globally stable periodic solution assumably exists, and all solutions converge to the periodic solutions. Then the seasonal attack rate becomes
For the special case \(\beta (t)=\bar{\beta }\) and \(\delta (t)=\bar{ \delta }\), when \(R^{P}_{0}=\frac{\bar{\beta } \gamma + \bar{\delta }(b+\epsilon m)}{( \alpha +\mu +m)\gamma }>\frac{\mu }{\varLambda }\), system (2) has the globally stable equilibrium point as follows:
Then the attack rate at equilibrium is given by
Again, we can analyze the upper and lower bounds on the attack rate in terms of the parameters.
Lemma 3.5
For any Tperiodic solution \((S(t),I(t),P(t))\) of system (2), we have the upper bound
Proof
Assume \((S(t),I(t),P(t))\) is a Tperiodic solution of system (2). Then we obtain
when \(S(t)>0\) and \(S(t) + I(t) \leq \frac{\varLambda }{\mu }\). □
Lemma 3.6
If \((S(t),I(t),P(t))\) is a Tperiodic solution of system (2), then
where \(\bar{I}= \frac{1}{T}\int _{0}^{T} I(t) \,dt\).
Proof
Obviously,
Therefore, we get
where \(\bar{I}= \frac{1}{T}\int _{0}^{T} I(t) \,dt\). □
Theorem 3.7
For any Tperiodic solution \((S(t),I(t),P(t))\) of system (2), we have
Proof
Hence,
Using Lemma 3.6, the upper and lower bounds are obtained. □
In the next section, we represent the numerical verification comparing to the theoretical results and generate numerical bifurcation diagram.
Numerical simulations
We use a Runge–Kutta 4th order method to investigate the numerical results starting from the initial point \((S(0),I(0),P(0))=(50,10,1)\), with \(\varLambda = 5.00\), \(\beta = 0.01\), \(\delta = 0.001\), \(\alpha = 0.20\), \(\mu = 0.05\), \(m = 0.20\), \(b = 0.10\), \(\epsilon = 0.05\), and \(\gamma = 0.80\). Figures 5 and 6 show dynamic behaviors of unforced SIS and SISP models, respectively.
In order to illustrate the impact of the salinity on both transmissions, namely hosttohost and environmenttohost transmissions, the salinity function is defined as a sinusoidal function with 1year period. Assume that the transmission rate \(\beta (t)\) and salinity function are inversely proportional. By assuming \(\beta _{\mathrm{min}}\) as a minimum transmission rate, we obtain
when \(\omega >0\) is an additional proportion effect of salinity. For simplicity, transmission rates \(\delta (t)\) are described by the same function as \(\beta (t)\) which is \(\delta (t) = \delta _{\mathrm{min}}(1+ \omega (1+\cos {2\pi t})/2)\). The chosen functions satisfy the form of seasonally forcing term, namely \(\beta (t) = \bar{\beta }+\beta _{0} (t)\), where \(\bar{\beta } = (1+\omega /2)\beta _{\mathrm{min}}\).
ω is a bifurcation parameter. The timeseries plots in Fig. 7(a), (c), (e) and phase plane plots in Fig. 7(b), (d), (f) illustrate the behavior of system (2) with different values of ω. Furthermore, the visualization of bifurcation diagram of forced SISP model is shown in Fig. 8, while the sets of parameters used in Figs. 7 and 8 have the same values.
For \(\omega = 0.05\), the trajectory is attracted by the diseasefree equilibrium point \(L_{0}\) and becomes stationary, as shown in Fig. 7(b). For \(\omega = 0.30\), \(L_{0}\) still remains the stable equilibrium point, but there are small oscillations before the trajectory reaches the equilibrium point (Fig. 7(d)). At last, for \(\omega = 0.55\), the trajectory becomes periodic with 1year period, as shown in Fig. 7(d), (f). These results coincide with the bifurcation diagram in Fig. 8.
Finally, the attack rates and the number of susceptible host are also calculated in Table 3, while parameters are as follows: \(\beta _{\mathrm{min}} = 0.01\), \(\delta _{\mathrm{min}} = 0.02\), \(\alpha = 0.40\), \(m = 0.10\), and \(\gamma = 0.50\). Additionally, the attack rates from Table 3, which are between 4099 to 4864, coincide with the upper bound of attack rate from theoretical result, which is 9125.
Discussion and conclusion
This model is an approximation to the realistic behaviors on the spread of diseases. Hostpathogen interactions are studied in two situations, namely unforced and forced models. Indeed, we carried out a theoretical analysis and compared the results with numerical simulation. We found that the basic reproduction number (\(R_{0}\) and \(R_{0}^{P}\)) acts as a major factor on the existence of the equilibrium points and their asymptotic stability. In particular, we examined the upper and lower bounds of attack rate.
Then we considered the seasonal force in terms of sinusoidal function with 1year period. The additional proportion effect of salinity (ω) represents the effect of salinity to the host’s immunity or salinity fluctuation in the culture site. We can conclude that if the effect of salinity is small enough, the infectious host and FLP will be extinct eventually. When the effect of salinity is increased, the infectious host and FLP survive for some time but eventually also die. Finally, if the effect of salinity is large enough, the susceptible host, the infectious host, and FLP coexist.
The value of attack rate (A) shows the occurrence of an infectious incident. As a conclusion, the higher effect of salinity causes higher attack rate. It implies the higher infectious incident.
These results coincide with our hypothesis that the lower salinity, the lower oyster’s immunity.
However, the contents described in this study are conducted by the authors of the paper. Research and Researchers for Industries Scholarship, Thailand Research Fund, does not necessarily agree or reflect the opinions of the research output.
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Funding
This research was financially supported by (1) the Department of Mathematics, Faculty of Science, Mahidol University, (2) the Centre of Excellence in Mathematics, Commission on Higher Education, and (3) Research and Researchers for Industries Scholarship, Thailand Research Fund.
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Sunthawanic, K., Bunwong, K. & Saejie, W. Hostpathogen interaction for larvae oysters with salinity dependent transmission. Adv Differ Equ 2019, 409 (2019). https://doi.org/10.1186/s1366201923392
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Keywords
 Attack rate
 Hostpathogen interaction
 Oyster larvae
 Timevarying parameter
 Salinitydependent transmission