 Research
 Open Access
 Published:
Dynamical properties of a fractional reactiondiffusion trimolecular biochemical model with autocatalysis
Advances in Difference Equations volume 2017, Article number: 369 (2017)
Abstract
In this paper, a reactiondiffusion trimolecular biochemical model with autocatalysis and fractionalorder derivative is proposed. We establish the existence and uniqueness of a positive solution to this system in a Besov space. Besides, for this system, we obtain stability, Hopf and Turing bifurcations and spatial patterns. These dynamic behaviors of this system are slightly different from those of its corresponding firstorder system. The difference is illustrated by performing some numerical simulations, through which our main results are verified.
Introduction
In this paper, we deal with a trimolecular autocatalytic biochemical model. The reaction mechanism is
in which A, B, U and V are chemical reactants and products. Moreover, nonnegative constants \(k_{i}\), \(i=1,1,2,3\), represent the reaction rates. It is assumed that the first step of the reaction process is reversible, that the last two steps of the reaction process are irreversible and that two molecules of U react with one molecule of V to create an additional molecule of U. This autocatalytic reaction creates a positive feedback loop, a common component of the regulatory network [1]. V is considered to be stable and does not decay on the relevant timescales of the system, whereas U can decay back to A. Each of these components could in reality represent multiple molecules, but for the sake of simplicity we consider them as single entities. Further, we assume that U and V are diffusible in a reactor, disregarding convective phenomena and considering an isothermal process only. Then, the above scheme can be described by the following nonlinear reactiondiffusion system:
where the mark \([\cdot ]\) represents the density of some chemical component. Δ is the Laplacian operator, showing the molecules’ diffusion, and \(d_{U}\) and \(d_{V}\) denote the Fickian diffusion coefficients of \([U]\) and \([V]\), respectively, which are assumed to be positive constants. To simplify system (1.1), we introduce the new dimensionless quantities
Substituting these new variables into (1.1), we have
Here, we assume that these biochemical reactions are limited to a bounded sufficiently regular domain \(\Omega \in \mathbb{R}^{N}\), where N is a spatial dimension number such as \(N=1,2\) or 3. Further, we assume that system (1.2a) is equipped with the Neumann boundary conditions,
where ν is the unit outward normal to ∂Ω. Besides, we set initial conditions for model (1.2a),
In fact, system (1.2a)(1.2c) is called Schnakenberg model [2]. At present, model (1.2a)(1.2c) has drawn some researchers’ attention. In detail, Liu et al. obtained the Turing and Hopf bifurcations of system (1.2a)(1.2c). Madzvamuse et al. in [3] applied theoretical analysis and numerical simulations to study a spatial pattern of the crossdiffusion form of (1.1). Based on this result, Gambino et al. in [4] used the StuartLandau equation to capture patterns of this model. Besides, Jacobo and Hudspeth in [5] utilized model (1.2a)(1.2c) to investigate pattern formation of hairbundle morphogenesis.
Model (1.2a)(1.2c) is an integerorder system, that is, the firstorder derivative and the secondorder derivative with respect to the time variable t and the spatial variable x, respectively. Wherein, the firstorder derivative to the variable t implies the transient change rate of these reactions. However, due to the complexity of biochemical reactions, chemical reaction processes are often affected by or depend on the history of chemical reactions. Thus, this phenomenon can be described by fractionalorder differential equations.
In fact, fractional calculus is an old mathematical topic developed as a pure theoretical field of mathematics for more than three centuries. Fractionalorder derivatives allow us to deal comfortably with memory effects in a dynamical system [6–8], and thus it can be successfully applied in some fields such as physics, control engineering, biochemical reaction, signal processing, optimal control, quantum mechanics [9, 10] and so on. At present, a large number of monographs and papers [11–21] are devoted to fractional dynamical systems. From this viewpoint, we introduce fractionalorder derivative into model (1.2a)(1.2c), which results in a completely different model. In fact, model (1.2a)(1.2c) ultimately turns into
where \(\frac{\partial^{\alpha }}{\partial t^{\alpha }}\) is the standard Caputo derivative, \(\alpha \in (0,1]\). As far as our knowledge goes, few literature works researched the dynamical properties of the fractionalorder model (1.3a)(1.3d) such as the existence of solution, stability and spatial patterns. In this paper, we first prove the existence and uniqueness of a solution in Besov spaces for model (1.3a)(1.3d) with low regularity initial data, which is a matter of interest in the mathematical analysis, as well as the existence of solution, stability and spatial patterns. Recently, the problem of initial data in Besov spaces has been widely considered. For instance, Zhai in [22, 23] studied the generalized KellerSegel system of chemotaxis. For more works dealing with PDEs in Besov spaces, we refer the readers to [24–26].
The outline of this paper follows here. In Section 2, some necessary lemmas and definitions are introduced. In Section 3, the solution to the fractionalorder PDEs model (1.3a)(1.3d) is established in Besov spaces. In Section 4 we study the stability and Hopf bifurcation of system (1.3a)(1.3d) and perform numerical simulations. In Section 5, we investigate the Turing bifurcation of system (1.3a)(1.3d), and some numerical simulations are made to show spatial patterns. Finally, we end our study with some conclusions.
Preliminaries
Definition 2.1
[12, 27] Caputo’s derivative of order q with the lower limit 0 for the function \(h:[0, \infty)\rightarrow \mathbb{R}\) can be written as
The space \(B^{\sigma }_{p,q,\mathcal{N}}\) denotes the Besov space in Ω with the Neumann boundary conditions. This space can be regarded as the real interpolation space \((L^{p}(\Omega), W^{2,p} _{\mathcal{N}})_{\sigma /2,q}\) for \(W^{2,p}_{\mathcal{N}}= \{ \varphi \in W^{2,p}(\Omega): \partial_{\nu }\varphi =0 \text{ on } \partial \Omega \} \). It is well known that the operators \(d_{1}\Delta + I\) and \(d_{2} \Delta \) are sectorial operators from \(W^{2,p}_{ \mathcal{N}}\) into \(L^{p}(\Omega)\), which are the infinitesimal generators of analytic and positive semigroups respectively denoted by \(G_{1}(t)\) and \(G_{2}(t)\). Thus, the following property holds:
where \(M_{1}\geq 1\) and \(\sigma \neq 1+1/p\). Moreover, if \(\sigma \leq \sigma '<2\) and \(\sigma '\neq 1+1/p\), then
see Theorem V.2.1.3 in [28]. Furthermore, if \(1< p<\infty \), \(\infty < s < \infty \) and \(1\leq q_{1} \leq q_{2} \leq \infty \), we have
Let \(\infty < s<\infty \), \(1< p< q<\infty \) and \(sN/p\geq N/q\), then
We are interested in mild solutions to (1.3a)(1.3d), i.e., there exists a pair \((u,v) \in C((0,\tau); B^{\sigma }_{p,q,\mathcal{N}}\times B ^{\sigma }_{p,q,\mathcal{N}})\) such that, for \(t>0\),
where
for \(i=1,2\), and \(\zeta_{\alpha }(\theta)\) is a probability density function defined on \([0,\infty)\) [29, 30], and Γ is a contour starting and ending at −∞. \(E_{\alpha,1}(\lambda)\) is a MittagLeffler function [27]. By the property of the semigroups \(G_{i}(t)\) for \(i=1,2\), the operators \(T_{\alpha }^{(i)}(t)\) and \(S_{\alpha }^{(i)}(t)\) for \(i=1,2\) are positive ones.
Consider the fractional system
where \(\alpha \in (0,1)\), \(A \in \mathbb{R}^{n\times n}\), \(f\in C^{1}( \mathbb{R}^{n},\mathbb{R}^{n})\), \(Df(0)=0\). The following lemma was proved in [31].
Lemma 2.2
System (2.7) with origin as a hyperbolic equilibrium point is linearly stable if each eigenvalue λ of A, \(\vert \arg (\lambda)\vert > \frac{\pi \alpha }{2}\); system (2.7) is linearly unstable if \(\vert \arg (\lambda)\vert <\frac{\pi \alpha }{2}\) for some eigenvalue λ of A.
Now, we consider a Hopf bifurcation of the fractional system with a parameter \(\mu \in \mathbb{R}\) as follows:
where \(\alpha \in (0,1)\), \(A(\mu) \in \mathbb{R}^{n\times n}\), \(f( \mu,x)\in C^{1}(\mathbb{R} \times \mathbb{R}^{n},\mathbb{R}^{n})\), \(Df( \mu,0)=0\).
It is well known that for system (2.8) with the firstorder derivative, Hopf bifurcation conditions are
The conditions of fractionalorder Hopf bifurcation differ from those of the firstorder case and are found in [32, 33], that is,
Existence and uniqueness of solution to (1.3a)(1.3d)
In this section, we will give out some necessary a priori estimates. First, we introduce some notations. Let \(\sigma \neq 1+1/p\). We look for a mild solution in the closed ball
Let us denote it by \(\mathcal{B}=\mathcal{B}(\tau, R, u_{0}, v_{0})\) for fixed \(\tau >0\) and \(R>0\). It is clear that \(\mathcal{B}\) is a complete metric space. We set
Next, we have the following.
Lemma 3.1
Let \(1< p<\infty \), \(\frac{2N}{3p}\leq \sigma <2\), \(\sigma \neq1+ \frac{1}{p}\) and \(1\leq q \leq 3p\). For \(u_{0}, v_{0} \in B^{\sigma }_{p,q,\mathcal{N}}\) and \((u,v)^{T} \in \mathcal{B}\), we have
and
where the constant \(E ( \theta^{1\frac{\sigma }{2}} ) \) is the expectation of the function \(\theta^{1\frac{\sigma }{2}}\) for the probability density function \(\zeta_{\alpha }(\theta)\).
Proof
For \(u,v \in L^{3p}(\Omega)\) and from (2.1), (2.3), (2.4) and (2.6a)(2.6c), we have
According to the properties of the probability density function \(\zeta_{\alpha }\), we conclude that \(E ( \theta^{1 \frac{\sigma }{2}} ) \) exists. Thus, we obtain (3.1). Analogously, we can get (3.2). □
Lemma 3.2
Let \(1< p<\infty \), \(\frac{2N}{3p}\leq \sigma <2\), \(\sigma \neq1+ \frac{1}{p}\) and \(1\leq q \leq 3p\). For \(u_{0}, v_{0} \in B^{\sigma }_{p,q,\mathcal{N}}\) and \((u_{i},v_{i})\in \mathcal{B}\), \(i=1,2\), we have
where
Proof
If \(u_{i},v_{i} \in L^{3p}(\Omega)\), \(i=1,2\), we have
Then
Thus, we get inequality (3.3). Using the same method, we can get inequality (3.4). □
Note that \(\zeta_{\alpha }(\theta)\) is onesided probability density function and that \(G_{i}(t)\), \(i=1,2\), are strong continuous contraction semigroups with respect to the variable t. By Lemma 3.1 we can take \(\tau_{1}>0\) small enough such that
and
We now define maps \(P_{i}: \mathcal{B} \rightarrow \mathcal{B}\) for \(i=1,2\), where
and
Theorem 3.3
Let \(1< p<\infty \), \(\frac{2N}{3p}\leq \sigma <2\), \(\sigma \neq1+ \frac{1}{p}\) and \(1\leq q \leq 3p\). Then, given \((u_{0},v_{0})^{T} \in B^{\sigma }_{p,q,\mathcal{N}}\), there exists a constant \(\tau >0\) such that problem (1.3a)(1.3d) has a unique locally mild positive solution \((u,v)^{T}: [0,\tau ] \rightarrow B^{\sigma }_{p,q, \mathcal{N}} \times B^{\sigma }_{p,q,\mathcal{N}}\).
Proof
The operators \(P_{i}(u,v): (0,\tau ]\rightarrow B^{\sigma }_{p,q, \mathcal{N}}\) for \(i=1,2\) are continuous maps for \(\frac{2N}{3p} \leq \sigma <2\) and \(\sigma \neq 1+\frac{1}{p}\). In fact, for \(0< t_{1}< t_{2}<\tau \) and \((u,v)^{T}\in B^{\sigma }_{p,q,\mathcal{N}} \times B^{\sigma }_{p,q,\mathcal{N}}\), we have
Since the operator \((ts)^{\alpha 1} G_{1} ( (ts)^{\alpha } \theta) \) is continuous with respect to the parameter \(t > s\) in the sense of the norm \(\mathcal{L}(B^{\sigma }_{p,q, \mathcal{N}})\), we can conclude
In the same way, we can show that if \(0< t_{1}< t_{2} <\tau \), then
Thus, for \(0\leq \sigma <2\), \(P_{i}(u,v): (0,\tau ] \rightarrow B ^{\sigma }_{p,q,\mathcal{N}}\) is a continuous map for \(i=1,2\).
Next, we will show \(P=(P_{1},P_{2}): \mathcal{B}\rightarrow \mathcal{B}\). In fact, it follows from estimates (3.5) and (3.1) that
and from (3.6) and (3.2) we have the following estimate:
Now, we will prove that the maps \(P_{i}: \mathcal{B} \rightarrow \mathcal{B}\), \(i=1,2\), are contractive ones in \(\mathcal{B}\). In fact, for \((u_{1},v_{1})^{T},(u_{2},v_{2})^{T} \in B^{\sigma }_{p,q,\mathcal{N}}\) with the same initial value \((u_{0},v_{0})^{T}\). According to Lemma 3.2, we take \(\tau_{2}\) such that \(M_{2} \tau_{2}^{\alpha ( 1\frac{\sigma }{2} ) }< \frac{1}{2}\). Let \(\tau =\min \{ \tau_{1},\tau_{2}\}\) and then we have
Then, by the Banach fixed point theorem, there exists a unique fixed point \((u,v)\in \mathcal{B}\), that is, the unique local mild solution of (2.5a)(2.5c) in \(\mathcal{B}\). By virtue of the positive property of the operators \(T_{\alpha }^{(i)}\) and \(S^{(i)}_{\alpha }\) for \(i=1,2\), this result is obtained. □
According to Theorem 3.3, there exists small enough \(\tau >0\) such that problem (1.3a)(1.3d) has a unique local mild solution defined in \(\mathcal{B}(\tau,R,u_{0},v_{0})\). This solution is bounded, i.e., \(\Vert u\Vert _{C([0,\tau ]:B^{\sigma }_{p,q,\mathcal{N}})}, \Vert v\Vert _{C([0,\tau ]:B^{\sigma }_{p,q,\mathcal{N}})} \leq \mathcal{R}= \max \{R+\Vert u_{0}\Vert _{B^{\sigma }_{p,q,\mathcal{N}}}, R+ \Vert v_{0}\Vert _{B^{\sigma }_{p,q,\mathcal{N}}}\}\). The mild solution of (1.3a)(1.3d) at \(t=\tau \) exists, which is denoted by \((u(\tau),v(\tau))^{T}\). We take \((u(\tau),v(\tau))^{T}\) as another initial value of (1.3a)(1.3d). Repeating the above discussion and by Theorem 3.3, we know that under the conditions in Theorem 3.3 the problem of (1.3a)(1.3d) with the initial value \((u(0),v(0))^{T}=(u(\tau),v( \tau))^{T}\) has a unique mild solution (denoted by \((u_{1}(t),v_{1}(t))\)) defined on the interval \([\tau,\tau_{1}]\), and this solution is bounded, that is, there exist two positive constants \(\mathcal{R}_{1}\), \(R_{1}\) such that \(\Vert u_{1}\Vert _{C([\tau,\tau_{1}]:B ^{\sigma }_{p,q,\mathcal{N}})}, \Vert v_{1}\Vert _{C([\tau,\tau_{1}]:B^{ \sigma }_{p,q,\mathcal{N}})} \leq \mathcal{R}_{1}= \max \{R_{1}+\Vert u(\tau)\Vert _{B^{\sigma }_{p,q,\mathcal{N}}}, R_{1}+ \Vert v(\tau)\Vert _{B^{ \sigma }_{p,q,\mathcal{N}}}\}\). Repeating this process over and over, a mild solution of (1.3a)(1.3d) is ultimately established on a maximum interval \((0,T_{\max })\). So, we have the following result.
Theorem 3.4
Let \(1< p<\infty \), \(\frac{2N}{3p}\leq \sigma <2\), \(\sigma \neq1+ \frac{1}{p}\) and \(1\leq q \leq 3p\). Then, given \((u_{0},v_{0})^{T} \in B^{\sigma }_{p,q,\mathcal{N}}\times B^{\sigma }_{p,q,\mathcal{N}}\), problem (1.3a)(1.3d) has a unique mild positive solution \((u,v)^{T}: [0,T_{\max }) \rightarrow B^{\sigma }_{p,q,\mathcal{N}} \times B^{ \sigma }_{p,q,\mathcal{N}}\).
Stability and Hopf bifurcation
In this section, we study the stability and Hopf bifurcation of a spatially homogeneous equilibrium point for (1.3a)(1.3d). System (1.3a)(1.3d) has a unique homogeneous steady state \(E_{0}=(u^{*},v ^{*})\)
which satisfies
Linearizing model (1.3a)(1.3d) at \(E_{0}\) yields
where
Let \(\{\mu_{k}, \varphi_{k}\}_{k=1}^{\infty }\) be an eigenpair of the operator −Δ on Ω with the Neumann boundary condition, where \(0=\mu_{1}<\mu_{2}<\cdots \) . \(E(\mu_{k})\) is the eigenspace corresponding to \(\mu_{k}\) in \(C^{1}(\overline{\Omega })\), and \(\varphi_{kj} \), \(j=1,2,\ldots\) , \(\dim E(\mu_{k})\), is an orthonormal basis of \(E(\mu_{k})\). Let
and \(X_{kj}=\{\mathbf{c} \varphi_{kj}\vert \mathbf{c}\in \mathbb{R}^{2}\}\). Consider the following decomposition:
where \(X_{k}= \bigoplus_{j=1}^{\dim E (\mu_{k})}X_{kj} \) and \(X_{kj}\) is the eigenspace corresponding to \(\mu_{k}\).
For each \(k\geq 1\), \(X_{k}\) is invariant under the operator \(L=D \Delta + J(E_{0})\), and λ is an eigenvalue of L on \(X_{k}\) if and only if it is an eigenvalue of the matrix \(\mu_{k}D+ J(E _{0})\). Denote
The characteristic equation of \(A(\mu_{k})\) is
where
If the following inequalities hold,
i.e.,
then the roots of (4.4) are negative for \(k \in \mathbb{N}\), so the homogeneous steady state \(E_{0}\) is stable. Recently, some literature works [32, 34, 35] have shown that time fractionalorder derivatives can induce stability of a steady state for a fractionalorder system although the corresponding characteristic roots at this steady state have positive real parts. To find another parameter region of the stability for (1.3a)(1.3d), one can check the parameters satisfying the following inequalities:
i.e.,
Under conditions (4.7), the characteristic roots of (4.4) for \(k=1\) obviously are complex with a positive real part. For this case, the corresponding firstorder derivative system of (1.3a)(1.3d) is unstable at \(E_{0}\). However, \(E_{0}\) might be stable for the fractionalorder system (1.3a)(1.3d). Denote the characteristic roots of (4.4) by
where \(P_{m} \) and \(Q_{m}\) belong to \(\mathbb{R}\) and \(i^{2}=1\). Let
and there exists a positive constant K such that \(\mu_{K} \leq \mu^{*}\) and \(\mu_{K+1} >\mu^{*}\). According to Lemma 2.2, \(E_{0}\) is stable if and only if the tangent of the characteristic roots
for \(k=1,\ldots,K\). Under condition (4.7), formula (4.5a) ((4.5b)) decreases (increases) with respect to \(\mu_{k}\) for \(k=1,\ldots,K\). Thus, in order to check the stability of \(E_{0}\), we only need to verify the condition
For the case of \(k=1\), after calculating (4.8), we obtain
i.e.,
From the above discussion, we can get the following result about the stability for system (1.3a)(1.3d).
Theorem 4.1
For system (1.3a)(1.3d), the spatially homogeneous equilibrium point \(E_{0}\) is stable if any of the following two conditions is satisfied:

(i)
\((a+b)^{3}> \max \{ ba,\frac{d_{2}(ba)}{d_{1}} \} \),

(ii)
\(\frac{d_{2}(ba)}{d_{1}}<(a+b)^{3}<ba\) and \({\frac{ 4 ( a+b) ^{4}}{ ( ( a+b) ^{3}+ ab) ^{2}}} > \tan^{2} ( \frac{\alpha \pi }{2} ) +1\).
For the corresponding firstorder system of (1.3a)(1.3d), \(E_{0}\) is stable if and only if condition (i) in Theorem 4.1 holds. However, for the fractionalorder system (1.3a)(1.3d), \(E_{0}\) is still stable under conditions (ii) in Theorem 4.1, except for condition (i), because the fractionalorder derivative can induce the stability. In addition, condition (ii) in Theorem 4.1 seems very complicated, but its parameter set is not empty. For example, take \(d_{1}=0.02\) and \(d_{2}=0.01\), and we plot Figure 1 to illustrate the parameter region of stability for (1.3a)(1.3d). In this figure, the parameters in region IV satisfy conditions (ii) in Theorem 4.1. \(E_{0}\) is stable for system (1.3a)(1.3d) with the parameters in regions IV, V and VI. For other parameters (such as regions I, II and III), \(E_{0}\) is unstable and around it spatially homogeneous periodic orbits arise, that is, a Hopf bifurcation happens.
To show the stability and spatially homogeneous periodic orbits of (1.3a)(1.3d), we will perform numerical simulations for system (1.3a)(1.3d) in a onedimensional space with parameters satisfying stable conditions. To this end, we discretize the space and the time of the problem because the dynamical behavior of system (1.3a)(1.3d) cannot be investigated by using analytical methods or normal forms. We will transform it from an infinitedimensional (continuous) to a finitedimensional (discrete) form. System (1.3a)(1.3d) is solved in a discrete domain with M lattice sites. The step length between the lattice points is defined by the lattice constant \(\Delta h=0.25\). In this discrete system, the Laplacian operator describing diffusion is calculated by using a three central difference scheme. The time evolution is also discrete, that is, the time goes by steps of \(\Delta t=0.02\), and is solved by an Adamstype predictorcorrector method for a fractionalorder equation. For simplicity, in this section, we take the spatial region \(\Omega =(0,10)\). In Figure 2, we choose the parameters \(a=0.08\) and \(b=0.3\) located in region I in Figure 1, and plot the spatially homogeneous periodic orbits. Besides, we also plot the spatially homogeneous periodic orbits of the corresponding time firstorder model of (1.3a)(1.3d) with the same parameters, see Figure 3. However, these two figures indicate that there exists some difference in the spatially homogeneous periodic orbits coming from system (1.3a)(1.3d) and its corresponding firstorder system, respectively. Compared with the firstorder system, the amplitude of the periodic orbit of the fractionalorder system (1.3a)(1.3d) is smaller. This shows that the amplitude of the periodic orbit of system (1.3a)(1.3d) is affected by the fractionalorder derivative. To discover the relationship between the amplitude and the fractionalorder derivative, we plot Figure 4. In this figure, the amplitudes of the periodic orbits of u and v increase with the fractional order α. We take \(a=0.042\) and \(b=0.626\) in region II in Figure 1 and respectively plot the spatially homogeneous periodic orbits of system (1.3a)(1.3d) and its corresponding firstorder system, see Figures 5 and 6. The amplitude of the spatially homogeneous periodic orbits of system (1.3a)(1.3d) are still smaller in comparison with the corresponding firstorder system. The similar results appear when the parameters are chosen in region III in Figure 1, see Figures 7 and 8.
Next, we will focus on some difference of the stability between the fractionalorder system (1.3a)(1.3d) and its corresponding firstorder system. First, in region IV in Figure 1 we choose parameters randomly, for example, \(a=0.14\) and \(b=0.54\). For these given parameters, the spatially homogeneous steady state is \(E_{0}=(0.68,1.678)\). System (1.3a)(1.3d) presents the stability of \(E_{0}\), see Figure 9, but its corresponding firstorder system presents the spatially homogeneous periodic orbits, see Figure 10. This phenomenon implies that the time fractionalorder derivative can induce the stability of system (1.3a)(1.3d) or that the fractional order can expand the parameter region of stability compared with its corresponding firstorder system. When the parameters a and b are chosen from region V or VI in Figure 1, the spatially homogeneous steady state \(E_{0}\) is stable for system (1.3a)(1.3d) and its corresponding firstorder system, see Figures 11 and 12. Here, we only illustrate for the parameters in region V and do not show any figure with the parameters chosen in region VI because of the similar results as shown in Figures 11 and 12.
Turing pattern
In the above section, we have obtained the stability and Hopf bifurcation of system (1.3a)(1.3d). However, these results focus on the spatial homogeneity of the dynamical behaviors of system (1.3a)(1.3d). The spatial heterogeneity (i.e., Turing pattern) is interesting and significant for a reactiondiffusion system, which breaks the homogeneous states because the Turing bifurcation occurs. In this section, we continue to investigate the Turing instability of system (1.3a)(1.3d). In particular, we will find difference of spatial patterns between system (1.3a)(1.3d) and its corresponding firstorder system. Turing patterns require two conditions. First, a nontrivial homogeneous steady state exists and is stable for spatially homogeneous perturbations. This condition is obtained in Theorem 4.1. Second, the stable steady state is unstable to at least one type of spatially heterogeneous perturbations. The second condition defines the condition for Turing instability, which ensures that local perturbations on the stable homogeneous steady state gradually expand globally.
Now, adding the heterogeneous disturbance term into the steady state \(E_{0}\) yields
where r̄ is the disturbance growth rate of t moment, i is the imaginary unit, k represents wave number, \(\bar{r}=(X,Y)\) is a twodimensional factor in the complex conjugate plane. After inserting the above equation into system (1.3a)(1.3d) and keeping the first degree term of ϵ, we obtain the characteristic equation as follows:
where
In order to produce the Turing pattern, the nontrivial homogeneous steady state \(E_{0}\) must be stable under spatially homogeneous perturbations. Note the condition of stability for a fractionalorder system (1.3a)(1.3d). We can find the following conditions of stability under spatially homogeneous perturbations:
or
Further, according to the second condition of forming Turing pattern, the spatially homogeneous steady state \(E_{0}\) destabilizes under some spatially heterogeneous perturbations. Thus, for some wave number k, equation (5.3b) must be less than zero. Consequently, we have
Here, according to inequalities (5.4a), (5.4b), we plot a parameter \(ab\) diagram to show the stability and instability of \(E_{0}\) under spatially homogeneous perturbations, see Figure 13(A). In this figure, if the parameters are chosen in regions II, III or IV, then \(E_{0}\) is stable under spatially homogeneous perturbations for the fractionalorder system (1.3a)(1.3d). However, for the corresponding firstorder system of (1.3a)(1.3d), the steady state \(E_{0}\) becomes unstable due to the parameters in region II. Besides, by inequalities (5.4a), (5.4b) and (5.5) we present Figure 13(B), which is also a parameter \(ab\) diagram in which Turing bifurcations can occur. In this figure, take \(d_{1}=0.01\), \(d_{2}=0.25\) and \(\alpha =0.8\), and the parameter \(ab\) diagram is divided into three segments: the homogeneous steady state region consisting of regions 3 and 4, pure Turing instability consisting of regions 2, 5 and 6 and HopfTuring instability consisting of only one region 1.
Next, we will perform numerical simulations of system (1.3a)(1.3d) in a twodimensional space with parameters satisfying Turing conditions to obtain Turing patterns. To this end, we should discretize the space and the time of the problem because the dynamical behavior of system (1.3a)(1.3d) cannot be investigated by using analytical methods or normal forms. We will transform it from an infinitedimensional (continuous) to a finitedimensional (discrete) form. System (1.3a)(1.3d) is solved in a discrete domain with \(M\times N\) lattice sites. The spacing between the lattice points is defined by the lattice constant \(\Delta h=0.25\). In this discrete system, the Laplacian operator describing diffusion is calculated by using a five central difference scheme. The time evolution is also discrete, that is, the time goes by steps of \(\Delta t=0.02\), and is solved by an Adamstype predictorcorrector method for fractionalorder equation. In order to avoid numerical artefacts, we checked the sensitivity of the results to the choice of the time and space steps, and their values have been chosen sufficiently small. Both numerical schemes are standard, hence we do not describe them here.
Set the parameters as follows: \(a=0.4\), \(b=0.5\), \(d_{1}=0.01\), \(d_{2}=0.25\) and \(\alpha =0.8\). Then these parameters are located in region 4 of \(ab\) diagram 13(B), and we have the positive equilibrium \((u^{*},v^{*})=(0.9,0.617)\). The initial density distributions are random spatial distribution of the species near \(E_{0}\), which is more general from biological point of view. We plot the evolution of the spatial patterns of prey and predator at 0 and 10,000 iterations, see Figure 14. This figure shows that the spatially homogeneous steady state \(E_{0}\) is stable.
Take the above parameters, but let \(a=0.2\) and \(b=0.8\), whose position is located in region 6 in Figure 13(B). System (1.3a)(1.3d) produces spatial patterns, see Figure 15. In Figure 15, (A) and (B) respectively show initial states of prey and predator. (C) and (D) show the pure Turing patterns of prey and predator, respectively. Meanwhile, we also simulate the corresponding firstorder system of (1.3a)(1.3d) with the same parameters, and the same patterns form as in Figure 15, which here is not displayed.
For the parameter chosen in region 2 of the parameter \(ab\) diagram 13(B), spatial patterns of (1.3a)(1.3d) and its corresponding firstorder system, however, are completely different, see Figure 16 with \(a=0.1\) and \(b=0.7\). We find that prey’s and predator’s patterns of system (1.3a)(1.3d) are spots, and that strip patterns appear for the corresponding firstorder system of (1.3a)(1.3d). The reason is that for the same parameters a and b, system (1.3a)(1.3d) produces pure Turing patterns, but its corresponding firstorder system does TuringHopf patterns. Finally, we numerically simulate system (1.3a)(1.3d) and its corresponding firstorder system with the parameters \(a=0.05\) and \(b=0.5\) chosen in region 1 in the parameter \(ab\) diagram 13B, and find that these two systems form the same patterns, see Figure 17. The reason is that these two kinds of systems have the same reaction field.
Conclusion and discussion
In this paper, for system (1.3a)(1.3d), which is a fractionalorder partial differential equation model, we have discussed the existence and uniqueness of the positive solution in a Besov space. Besides, we have obtained stability, Hopf bifurcation, Turing bifurcation and spatial patterns of this model. From theoretical analysis and numerical simulations, we find some difference between system (1.3a)(1.3d) and its corresponding firstorder system on the stability, Hopf bifurcation and spatial patterns. In detail, the fractionalorder derivative enlarges the parameter region of the stability in comparison with its corresponding firstorder system. Besides, these two systems with the same parameters can form different spatial patterns (see Figure 16). These results, as far as our knowledge goes, are completely new. So far, there are few literature works to study fractionalorder partial differential equations. This kind of equations are still open, such as Hopf bifurcation direction, normal form and their application, which are worth being investigated in the future.
References
 1.
Mellman, I, Misteli, T: Computational Cell Biology. Springer, Berlin (2002)
 2.
Liu, P, Shi, J, Wang, Y, Feng, X: Bifurcation analysis of reactiondiffusion Schnakenberg model. J. Math. Chem. 51, 20012019 (2013)
 3.
Madzvamuse, A, Ndakwo, HS, Barreira, R: Crossdiffusiondriven instability for reactiondiffusion systems: analysis and simulations. J. Math. Biol. 70, 709743 (2015)
 4.
Gambino, G, Lupo, S, Sammartino, M: Effects of crossdiffusion on Turing patterns in a reactiondiffusion Schnakenberg model (2015). arXiv:1501.04890
 5.
Jacobo, A, Hudspeth, AJ: Reactiondiffusion model of hairbundle morphogenesis. Proc. Natl. Acad. Sci. 111, 1544415449 (2014)
 6.
Du, M, Wang, Z, Hu, H: Measuring memory with the order of fractional derivative. Sci. Rep. 3, 3431 (2013)
 7.
Maraaba, T, Baleanu, D, Jarad, F: Existence and uniqueness theorem for a class of delay differential equations with left and right Caputo fractional derivatives. J. Math. Phys. 49, 083507 (2008)
 8.
Babakhani, A, Baleanu, D, Agarwal, RP: The existence and uniqueness of solutions for a class of nonlinear fractional differential equations with infinite delay. Abstr. Appl. Anal. 2013, 592964 (2013)
 9.
Bhrawy, AH, Zaky, MA: Highly accurate numerical schemes for multidimensional space variableorder fractional Schrödinger equations. Comput. Math. Appl. 73, 11001117 (2017)
 10.
Zaky, MA, Machado, JAT: On the formulation and numerical simulation of distributedorder fractional optimal control problems. Commun. Nonlinear Sci. Numer. Simul. 52, 177189 (2017)
 11.
Klages, R, Radons, G, Sokolov, IM: Anomalous Transport: Foundations and Applications. Wiley, New York (2008)
 12.
Kilbas, AA, Srivastava, HM, Trujilio, JJ: Theory and Applications of Fractional Differential Equations. Elsevier, Amsterdam (2006)
 13.
Wang, J, Zhou, Y: MittagLefflerUlam stabilities of fractional evolution equations. Appl. Math. Lett. 25, 723728 (2012)
 14.
Angstmann, CN, Henry, BI, McGann, AV: A fractional order recovery SIR model from a stochastic process. Bull. Math. Biol. 78, 468499 (2016)
 15.
Chang, YK, Zhang, R, N’Guerekata, GM: Weighted pseudo almost automorphic mild solutions to semilinear fractional differential equations. Comput. Math. Appl. 64, 31603170 (2012)
 16.
Bostan, M: Strongly anisotropic diffusion problems; asymptotic analysis. J. Differ. Equ. 256, 10431092 (2014)
 17.
Wang, J, Zhou, Y: A class of fractional evolution equations and optimal controls. Nonlinear Anal., Real World Appl. 12, 262272 (2011)
 18.
Sakthivel, R, Revathi, P, Ren, Y: Existence of solutions for nonlinear fractional stochastic differential equations. Nonlinear Anal., Theory Methods Appl. 81, 7086 (2013)
 19.
Guo, G, Chen, B, Zhao, X, Zhao, F, Wang, Q: First passage time distribution of a modified fractional diffusion equation in the semiinfinite interval. Phys. A, Stat. Mech. Appl. 433, 279290 (2015)
 20.
Tchier, F, Inc, M, Korpinar, ZS, Baleanu, D: Solutions of the time fractional reactiondiffusion equations with residual power series method. Adv. Mech. Eng. 8, 110 (2016)
 21.
Bhrawy, AH, Baleanu, D, Mallawi, F: A new numerical technique for solving fractional subdiffusion and reaction subdiffusion equations with a nonlinear source term. Therm. Sci. 19, 2534 (2015)
 22.
Zhai, Z: Wellposedness for two types of generalized KellerSegel system of chemotaxis in critical Besov spaces. Commun. Pure Appl. Anal. 10, 287308 (2011)
 23.
Zhai, Z: Global wellposedness for nonlocal fractional KellerSegel systems in critical Besov spaces. Nonlinear Anal., Theory Methods Appl. 72, 31733189 (2010)
 24.
Prömel, DJ, Trabs, M: Rough differential equations driven by signals in Besov spaces. J. Differ. Equ. 260, 52025249 (2016)
 25.
Yan, K, Qiao, Z, Zhang, Y: Blowup phenomena for an integrable twocomponent CamassaHolm system with cubic nonlinearity and peakon solutions. J. Differ. Equ. 259, 66446671 (2015)
 26.
Zhao, J, Liu, Q, Cui, S: Existence of solutions for the DebyeHückel system with low regularity initial data. Acta Appl. Math. 125, 110 (2013)
 27.
Morel, JM, Takens, F, Teissier, B: The Analysis of Fractional Differential Equations. Springer, Berlin (2004)
 28.
Amann, H: Linear and Quasilinear Parabolic Problems: Volume I: Abstract Linear Theory, vol. 1. Springer, Media (1995)
 29.
ElBorai, MM: Some probability densities and fundamental solutions of fractional evolution equations. Chaos Solitons Fractals 14, 433440 (2002)
 30.
Cao, J, Yang, Q, Huang, Z: Optimal mild solutions and weighted pseudoalmost periodic classical solutions of fractional integrodifferential equations. Nonlinear Anal., Theory Methods Appl. 74, 224234 (2011)
 31.
Matignon, D: Stability results for fractional differential equations with applications to control processing. Comput. Eng. Syst. Appl. 2, 963968 (1997)
 32.
ElSaka, HA, Ahmed, E, Shehata, MI, ElSayed, AMA: On stability, persistence, and Hopf bifurcation in fractional order dynamical systems. Nonlinear Dyn. 56, 121126 (2008)
 33.
Ahmed, E, ElSayed, AMA, ElSaka, HAA: Equilibrium points, stability and numerical solutions of fractionalorder predatorprey and rabies models. J. Math. Anal. Appl. 325, 542553 (2007)
 34.
Huang, S, Wang, B: Stability and stabilization of a class of fractionalorder nonlinear systems for \(0<\alpha <2\). Nonlinear Dyn., 112 (2016)
 35.
Delavari, H, Baleanu, D, Sadati, J: Stability analysis of Caputo fractionalorder nonlinear system revisited. Nonlinear Dyn. 67, 24332439 (2012)
Acknowledgements
We thank for helpful comments of referees. This work is supported by grants 61563033, 11563005 and 11563005 from the National Natural Science Foundation of China, and 20161BAB201010 from the Natural Science Foundation of Jiangxi Province.
Author information
Affiliations
Contributions
All authors read and approved the final manuscript.
Corresponding author
Correspondence to Hongwei Yin.
Ethics declarations
Competing interests
The authors declare that they have no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
About this article
Received
Accepted
Published
DOI
Keywords
 Caputo’s derivative
 reactiondiffusion trimolecular model
 Besov spaces
 spatial patterns
 Hopf and Turing bifurcations