Theory and Modern Applications
Table 2 Parameters in the model (adapted from [ 1 , 5 , 6 , 15 ])
Parameter | Definition |
|---|---|
Λ | Constant production rate of healthy CD4+ T-cells from precursors |
\(d_{T}\) | Natural death rate of healthy CD4+ T-cells |
r | Logistic growth rate of healthy CD4+ T-cells |
\(T_{\mathrm{max}}\) | Carrying capacity of healthy CD4+ T-cells |
k | Infection rate of healthy CD4+ T-cells by free infectious virus |
η | Fraction of infections leading to latently infected CD4+ T-cells |
\(d_{L}\) | Death rate of latently infected CD4+ T-cells |
\(d_{I}\) | Death rate of productively infected CD4+ T-cells |
a | Activation rate from latently to productively infected CD4+ T-cells |
N | Average number of free virus released by a productively infected CD4+ T-cell during its mean lifetime \(1/d_{I}\) |
c | Clearance rate of free virus |
\(n_{rt}\) | Drug efficacy of RTI \((0 \leq n_{rt} < 1)\) |
\(n_{p}\) | Drug efficacy of PI \((0 \leq n_{p} < 1)\) |
Ï„ | Time delay for transformation from latently to productively infected CD4+ T-cells |