 Research
 Open Access
Modeling and analysis of the secondary routine dose against measles in China
 Yiming Li^{1},
 Jie Wang^{2}Email author,
 Bo Sun^{3},
 Jianliang Tang^{4},
 Xizhuang Xie^{5} and
 Shuping Pang^{1}
https://doi.org/10.1186/s1366201711252
© The Author(s) 2017
 Received: 22 October 2016
 Accepted: 24 February 2017
 Published: 27 March 2017
Abstract
Measles remain to be an important global public health issue in China. In spite of large coverage rates of the first dose of Measles mumps rubella (MMR) combination vaccines (MMR1), large numbers of measles cases continue to be reported in China in recent years due to the high incidence and the low coverage of the second MMR vaccine dose (MMR2). This paper is devoted to modeling the combined effects of MMR1 and MMR2 coverage rates on the controlling of measles. To do that, we propose and study a robust timedelayed compartment measles infection model where MMR2 is followed after a fixed time interval of MMR1, and the combined elements of infection and mass immunization are also considered. By using the methods of Lyapunov functional and the uniform theory for infinitedimensional dynamical systems, a threshold dynamics determined by the basic reproduction number \(\Re_{0}\) is established: the measles can be eradicated if \(\Re_{0}<1\), whereas the disease persists if \(\Re_{0}>1\). Moreover, it is shown that the endemic equilibrium is locally asymptotically stable once \(\Re_{0}>1\). Numerical simulations are performed to support the theoretical results and to consider the effects of MMR2 on the controlling of measles. Our results show that to eliminate measles in China, we should have MMR1 coverage rates larger than 88.01% based on perfect MMR2 coverage, and have MMR2 coverage rates larger than 92.63% based on perfect MMR1 coverage; Moreover, our simulations suggest that there is a risk that paradox of vaccination against measles in China may occur: that is, the final size of infected individuals may even increase in spite of the increase of MMR2 coverage rates.
Keywords
 measles model
 second dose
 Lyapunov function
 globally asymptotic stability
 basic reproductive number
MSC
 92D25
 34K20
1 Introduction
Measles is one of the most contagious viral diseases, spreading especially rapidly in populations that are dense and/or exhibit low immunity [1, 2]. In 1963, the United States approved measles virus vaccine (MV), and in the 1970s, MV were widely applied in other parts all around the world [3, 4]. The vaccine can provide with protection longer than 20 years, and its immunity can be seen as lifelong time, the efficiency of the vaccine reaches above 80% [3, 5]. Because the antibodies produced by the vaccine are interfered by maternaltransferred one, the efficiency of vaccine, which reaches 95%98%, improves after six months and reaches the peak when the infant becomes 1215 months old [5, 6]. In the late 1980s, most countries have listed measles vaccine to their regular immune plans, and the coverage of the vaccines sees a huge improvement. In 1990, reported coverage of measles vaccine for 2yearolds has taken up 70% of all infants under 2 years old [2, 6]. Since 1990, in World Heath Organization (WHO) Americas, plan on eliminating measles has reduced cases by 99% and higher, and the cases for death are close to zero [4, 7]. Strategies for the plan include maintaining a high coverage rate by carrying out children’s vaccine plan. In WHO West Pacific, and WHO Africa, WHO Europe, WHO East Mediterranean, and WHO Southeast Asia, controlling on measles has also made big process [7, 8].
In China, the national Expanded Program on Immunization (EPI) of a 2dose monovalent MV schedule was implemented in 1986, with the first dose of vaccine at 8 months (monovalent attenuated vaccine, HU191 or CHANG47 strain) and the second dose at 7 years of age average [1, 5]. In 2006, the national committee for measles elimination of China executed the National Measles Elimination Plan (NMEP) [7, 9], which includes the MMR2 is to be administered at 1824 months, and all measles vaccinations are free of charge. Although China has made great progress in measles control in the framework of the NMEP, its reported rate of measles was 28 cases per million in 2010, still far above the WHO’s recommended rate of one case per million [2, 10, 11]. The key contributors of measles outbreaks in China include the mobility and complexity of population, the age structure changing of measles cases and the own limitations of MV, which induce the recurrence and epidemic of measles. Especially in the communities of floating population where coverage rates of MMR1 and MMR2 are much lower than the national average rates [2, 12], the measles rate continuously increases or keeps at higher level [7, 12]. Besides, the efficiency of vaccine cannot reach 100%, many children have never been vaccinated and are still susceptible to measles, and a small number children are susceptible because of the primary immunity fail [6, 13].
For the overall world, WHO suggested an MMR2 based on MMR1 to ensure the validity of immune and the prevention of the breakout, and WHO proposed the plan to achieve the regional measles elimination goals in 2015. However, new data show that overall progress toward increasing global immunization coverage has stagnated in recent four years and the 2015 measles elimination goals set by WHO Member States will not be achieved on time [7, 14]. Furthermore, comments on MMR2 are different both domestically and internationally, and problems are also exposed for the monitoring and management of measles cases, which include miss out of case report, error for case report, lack of enough information put monitor, and control on measles breakout of very difficult situation [7, 12]. Although the total of measles cases in some regions had gone down, measles still breaks out in other countries such as Angola, Ethiopia, India, Russia, and China. Therefore, the problem on the effects of MMR on measles prevention has attracted many studies in recent years, including works via mathematical model [15–19]. Baucha et including works via mathematical model [15–19]. Baucha et al. [20] developed an agestructured MSEIRV compartmental model, whereby individuals are allocated into one of a number of mutually exclusive categories based on their epidemiological status and age. Babad et al. [15] employed a discrete agespecific mathematical model to predict the impact of measles vaccination in England and Wales. Motivated by these interesting works, in this paper, we introduce a discrete time delay to describe the fixed time interval between MMR1 and MMR2, and we consider the effects of MMR2 on the measles prevention in China. Our study seems to be the first attempt in applying the structured model with time delay to addressing the dynamical changes of those susceptible and those MMR1 during the time interval between MMR1 and MMR2.
The rest of this paper is organized as follows. In Section 2, based on the epidemic model of SIR, we formulate a structured mathematical model to examine the effects of MMR2 on measles prevention. In Section 3, we identify the basic reproduction number and establish a global threshold dynamics for our model. In Section 4, we conduct numerical simulations to confirm our analytical results. We conclude this paper in Section 5 with a summary and discussion.
2 The model

We assume that the measles infections only occur among the children aged less than 14 years old since most of the reported measles cases in China are at the age of less than 14 years [7, 10].

For the infants N at the age of less than 8 month, they are maternally immune to measles. We assume that they have constant birth and death rates. Moreover, when they survive at the age of 8 months, they receive MMR1 with constant vaccination rate \(\rho_{1}\eta_{1}\) to get MMR1induced immunity for measles, where \(\rho_{1}\) is the effective rate for MMR1, and \(\eta_{1}\) is the injection rate for MMR1.

For those vaccinated individuals with MMR1induced immunity, that is, \(V_{1}\), we suppose they are always immune to measles before the MMR2 scheduled time and they has constant death rate \(d'\); moreover, we assume that there is a fixed time interval τ between the MMR1 and MMR2 scheduled time [1, 2].

For those the infants N who do not receive MMR1 at the age of 8 months, or who get MMR1 failure, they are assumed to lose the maternal immunity and become the susceptible compartment S to measles unless they receive MMR2 in future. From our assumptions it follows that the covering rate of these infants is \(1\rho_{1}\eta_{1}\).

Since the incubation period of measles is only from 9 to 12 days, which is too short compared with the whole immunity period of 1.5 years, the effect of incubation period on the measles immune control is ignored.

Those \(V_{1}\) who survived in the fixed time interval τ take MMR2 with constant vaccination rate \(\rho_{2}\eta_{2}\) to get MMR2induced immunity for measles, where \(\rho_{2}\) is the effective rate of \(V_{1}\) for MMR2, and \(\eta_{2}\) is the injection rate of \(V_{1}\) for MMR2.
To calculate the surviving probability, we have that \(V_{1}(t)\) satisfies the following equation for all t between the age of 8 month and 8 \(\mathrm{months}+\tau\):and thus we have \(V_{1}(t+\tau)=V_{1}(t) \cdot e^{d^{\prime}\tau}\), and we get the surviving rate \(V_{1}(t+\tau)/V_{1}(t)= e^{d^{\prime}\tau}\).$$\frac{{ d}V_{1}(t)}{{ d}t}=d^{\prime}V_{1}(t), $$ 
Those \(V_{1}\) who do not receive MMR2 at scheduled time or who get MMR2 failure become the compartment \(\tilde{V}_{1}\) with waning MMR1induced immunity.

The vaccinated individuals with MMR2induced immunity, that is, \(V_{2}\), are always immune to measles before they become 14 years old.

Those S who survived at the period before MMR2 scheduled time have constant rate \(\rho'_{2}\eta'_{2}\) to get MMR2induced immunity for measles, where \(\rho'_{2}\) is the effective rate of S for MMR2, and \(\eta'_{2}\) is the injection rate of S for MMR2.
To calculate the surviving probability, we have that \(S(t)\) satisfies the following equation for all t between the age of 8 month and 8 \(\mathrm{months}+\tau\):thus, we have$$\frac{{ d}S(t)}{{ d}t}=dS(t)\beta S(t)I(t), $$so that the surviving rate is \(e^{{\int^{t}_{t\tau}}(d+\beta I(\sigma))\,d\sigma}\), which is the probability remaining for susceptible persons.$$S(t+\tau)=S(t) \cdot e^{{\int^{t}_{t\tau}}(d+\beta I)\,d\sigma}, $$
Variables of the models given by assumptions
Symbol  Definition 

S  Number of susceptible individuals (between the age of 8 months14 years) 
I  Number of infected individuals (at the age under 14 years) 
R  Number of recovered individuals (under the age of 14 years) 
\(V_{1}\)  Number of vaccinated individuals with MMR1induced immunity (between the age of 824 months) 
\(V_{2}\)  Number of vaccinated individuals with MMR2 (between the age of 18 months14 years) 
\(\tilde{V}_{1}\)  Number of individuals with waning MMR1induced immunity between the age of 18 months14 years 
N  Number of new born susceptible individuals less than 8 months old 
Parameters and values used in assumptions
Symbol  Definition  Range  Baseline  Unit  Reference 

N̅  Total population    \(\lambda_{0}/(d'+1)\)  People  
\(\lambda_{0}\)  Birth rate    20.75  People Years^{−1}  
d  Nature death and mature rate    0.069  Years^{−1}  
β  Infection rate for S  0.080.3  0.1  People^{−1} Years^{−1}  
\(\beta'\)  Infection rate for \(\tilde{V}_{1}\)  0.00880.099  0.011  People^{−1} Years^{−1}  
γ  Recovery rate  01  0.9  Years^{−1}  
δ  The proportion of \(\tilde{V}_{1}\) degenerated into S  0.020.05  0.02  Years^{−1}  
\(d^{\prime}\)  Childhood mortality rate    0.00743  Years^{−1}  
\(\eta_{1}\)  Injection rates for MMR1  0.7231  0.91    
\(\eta_{2}\)  Injection rates of \(V_{1}\) for MMR2  0.31      
\(\eta_{2}^{\prime}\)  Injection rates of S for MMR2  0.31      
τ  Time interval between MMR1 and MMR2  1.31.5  1.5  Years  
\(\rho_{1}\)  Effective rate for MMR1  0.7241  0.98    
\(\rho_{2}\)  Effective rate of \(V_{1}\) for MMR2  0.8571  0.94    
\(\rho'_{2}\)  Effective rate of S for MMR2  0.8571  0.94   
3 Mathematical analysis
In this section, we analyze the stability of system (4).
3.1 Positiveness and boundedness of solutions
Let \(X(t)=(S(t), I(t))\) be a solution to system (4), Using similar methods to [29, 30], it is clear that it suffices to verify that the set \(X(t)\) is positively invariant for system (4).
Proposition 1
Let \(X(t)\in R_{+} \times C^{+}\) be the solution of system (4) with the initial condition (5). Then \(S(t)>0\) and \(I(t)> 0\) for all \(t> 0\).
Proof
By the second equation of (4) we have \(I(t)=I(0)e^{\int_{0}^{t}(\beta S\gammad)\,d\sigma}>0\) for all \(t>0\). From the first equation of (4), noting that \(A>B\), by similar arguments we have \(S(t)>0\) for all \(t>0\). □
Proposition 2
Let \(X(t) \in R_{+} \times C^{+}\) be the solution of system (4) with the initial condition (5). Then \(S(t)\) and \(I(t) \) are ultimately bounded.
Proof
For system (4), we have \(\dot{S}(t)< AdS\), \(t\geq0\), and thus \(\limsup_{t\rightarrow+\infty}S(t)\leq A/d\). By constructing the similar function \(\bar{W}=S+I\) and using similar arguments to [29, 30], we can prove that (4) is ultimately bounded. Thus, we get that \(I(t)\) is eventually bounded. □
3.2 The equilibria
Proposition 3
Proof
3.3 Main results
In this section, we consider the asymptotical dynamics of system (4). We will construct a Lyapunov functional, and using the LaSalleLyapunov theorem, we will study the characteristic equation of system (4).
Theorem 1
The diseasefree equilibrium \(E_{0}= (S_{0}, I_{0} )\) is globally asymptotically stable when \(\Re_{0}<1\) and unstable when \(\Re_{0}>1\).
Proof
From Proposition 2 we see that \(S\leq S_{0}\) for sufficiently large t. Thus, the function \(\frac{dW }{dt}\vert_{ \text{(4)}} \) is always nonpositive for any functions \(S(t), I(t)> 0\) when \(\Re _{0}<1\), and \(\frac{dW}{dt}\vert_{ \text{(4)}}=0\) if and only if \(S=S_{0}\), \(I=I_{0}\). By the LaSalleLyapunov theorem ([34], Thm. 3.4.7), the largest compact invariant set of {\(\mathcal{F}=\frac{dW}{dt}\vert_{ \text{(4)}}=0\)} is the singleton point \(E_{0}\). Thus, we conclude that \(E_{0}\) is globally attractive in \(\mathcal{F}\). From the above we see that the diseasefree equilibrium \(E_{0}= (S_{0}, 0 )\) is globally asymptotically stable when \(\Re_{0}<1\). This completes the proof. □
By applying the methods and techniques of persistence theory introduced in Zhao [28] for infinitedimensional systems, which have been recently employed in [29, 30, 35], we have the following:
Theorem 2
Suppose the basic reproduction number \(\Re _{0} > 1\). Then system (4) is uniformly persistent, that is, there exists a positive constant \(\epsilon>0\) such that every solution \((S(t), I(t)) \) of (4) satisfies \(\liminf_{t\to\infty} I(t) \geq\epsilon\).
We omit the proofs for Theorem 2 since they are very similar to those for [29], Thm. 5, [35], Thm. 2, and [30], Thm. 3.3; we refer the interested readers to these references.
Furthermore, by studying the stability of the endemic equilibrium of model (4), we have the following:
Theorem 3
The endemic equilibrium \(E^{*}= (S^{*}, I^{*} )\) is locally asymptotically stable when \(\Re_{0}>1\).
Proof
Step 1. We prove that the roots of the polynomial \(P(\zeta)=0\) only have negative real parts when \(\tau=0\).
Step 2. We prove that \(\zeta=0\) is not a root for \(p(\zeta)=0\) for any \(\tau>0\).
Step 3. We prove that there is no imaginary root for the characteristic equation evaluated at the infected steady state of system (3) when \(\tau>0\).
With all these three steps, we have proved that as τ increases from \(\tau=0\), the real parts of roots for \(p(\zeta)=0\) cannot be zero; indeed, ζ can neither be a zero root nor be an imaginary root. Therefore, we show that the real roots of the polynomial \(p(\zeta)=0\) must always be negative for any \(\tau\geq0\). This completes the proof. □
4 Numerical simulations
In this section, we conduct numerical simulations to confirm and extend our analytical results.
5 Summary and discussion

Our Theorems 1, 2, and 3 show that the measlesfree or measlesendemic only depends on the basic reproductive number \(\Re_{0} \).

The basic reproductive number \(\Re_{0} \) is a decreasing function on \(\eta_{1}\), that is, the coverage rates of MMR1, and on \(\eta_{2}\), \(\eta_{2}^{\prime}\), that is, the coverage rates of MMR2 for \(V_{1}\) and S. By increasing MMR2 rate we can reduce the basic reproductive number \(\Re_{0} \) and achieve the goal of control disease outbreaks by making \(\Re_{0}<1 \).

Our results show that to eliminate measles in China, we should have MMR1 coverage rates \(\eta_{1}\geq88.01\%\) based on \(\eta_{2}= \eta _{2}^{\prime}=100\%\); on the other hand, for MMR2, we should have \(\eta _{2}\geq92.63\%\) based on \(\eta_{1} =100\%\). A recent study on migrant children in east China shows that the MMR2 coverage rates are 44.7% [2], which will surely result in outbreak of measles.

We have also performed numerical studies of system (4). The parameter values are taken mainly from [2, 22, 25, 35]. We can observe that system (4) has 13 parameters, and discussing the impact of each in detail is neither relevant nor revealing. However, as observed in the uniform persistence and stability conditions, the epidemiological parameter β is also important and may provide significant variations in the system dynamics.

Interesting results from our simulations show that, given low coverage of MMR1 (say, \(\eta_{1}<0.7\)), the final size of infected individuals \(I^{*}\) may even increase in spite of the increase of MMR2 coverage rates, indicating some kind of paradox of vaccination, which had been found and studied in [36] for vaccination against avian flu epidemics. A recent study in [2] on migrant children in east China shows that the MMR1 coverage rates on these special groups are 0.769, which is close to 0.7, suggesting that there is a risk that paradox of vaccination against measles in China may occur.
Finally, we see that there are many other valuable problems in this area. For example: (1) We ignore the significant variance on MMR2 coverage rate for some different communities [7]; (2) We ignore the influences of subsequent supplementary immunization on measles control; (3) We ignore the influences of incubation period on measles control. We leave these questions for our future work.
Declarations
Acknowledgements
The authors would like to express their gratitude to the referees and the editor for their constructive, scientific thorough suggestions and comments on the manuscript. This work is partially completed during Y. Li’s visit to Harbin Institute of Technology. She would like to acknowledge the hospitality received there and the support of Visiting Scholar Program by the Department of Education, Heilongjiang Province.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Authors’ Affiliations
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