From: Viral dynamics of an HIV model with latent infection incorporating antiretroviral therapy
Paras | Definition | Unit | Data1 | Data2 | Data3 | Range | Source |
---|---|---|---|---|---|---|---|
λ | T-cells source term | \(\mu l^{-1}~\mbox{day}^{-1}\) | 10 | 10 | 10 | 1-10 | [4, 11, 12, 20] |
\(d_{T}\) | Death rate of healthy T-cells | day^{−1} | 0.03 | 0.01 | 0.01 | 0.01-0.1 | [4, 11, 12, 20] |
r | Growth rate of T-cells | day^{−1} | 0.1 | 0.03 | 0.1 | 0.03-0.1 | [20] |
\(T_{\max}\) | Carrying capacity of T-cells | \(\mu l^{-1}\) | 1,500 | 1,500 | 1,500 | 1,500 | [20] |
k | Infection rate | \(\mu l~\mbox{day}^{-1}\) | 10^{−4} | 10^{−4} | 10^{−4} | 10^{−5}-10^{−2} | [4, 11, 12, 16, 20] |
η | Fraction of infections that result in latency | 0.02 | 0.001 | 0.5 | 0.001-0.5 | [4, 11, 12] | |
\(d_{L}\) | Death rate of latently infected T-cells | day^{−1} | 0.001 | 0.004 | 0.2 | 0.001-0.2 | [4, 11, 12] |
a | Transition rate | day^{−1} | 0.1 | 0.01 | 0.3 | 0.01-0.3 | [4, 11, 12] |
δ | Death rate of infected T-cells | day^{−1} | 1 | 1 | 0.8 | 0.5-1.4 | [4, 11, 12, 20] |
N | Burst term | virions/cell | 1,000 | 200 | 500 | 200-3,000 | [4, 11, 12, 16, 20] |
c | Clearance rate of virus | day^{−1} | 20 | 3 | 15 | 3-36 | [4, 11, 12, 20] |
\(n_{rt}\) | RTI efficacy | 0.4, 0.5, 0.7 | 0.4 | 0.3 | 0-1 | - | |
\(n_{p}\) | PI efficacy | 0.5, 0.6, 0.8 | 0.5 | 0.4 | 0-1 | - |