An Effective Numerical Method and Its Utilization to Solution of Fractional Models Used in Bioengineering Applications
© Ivo Petráš. 2011
Received: 13 December 2010
Accepted: 1 February 2011
Published: 1 March 2011
This paper deals with the fractional-order linear and nonlinear models used in bioengineering applications and an effective method for their numerical solution. The proposed method is based on the power series expansion of a generating function. Numerical solution is in the form of the difference equation, which can be simply applied in the Matlab/Simulink to simulate the dynamics of system. Several illustrative examples are presented, which can be widely used in bioengineering as well as in the other disciplines, where the fractional calculus is often used.
Recently, fractional calculus has played an increasing role in modeling complex phenomena in the fields of physics, chemistry, biology, and engineering (e.g., [1–4]). The main characteristic of fractional derivatives, or more precisely derivatives of positive real order, is so called the "memory effect". It is well known that the state of many systems (biological, electrochemical, viscoelastic, etc.) at a given time depends on their configuration at previous times. The fractional derivative takes into account this history in its definition as a convolution with a function whose amplitude decays at earlier times as a power-law. Thus, the fractional derivative is natural to use when modeling biological systems in various bioengineering applications.
In this paper, we offer applications of fractional calculus in bioengineering, which are described by the fractional differential equations. Paper is organized as follows: basic definitions of fractional calculus, fractional-order systems and numerical method are presented first in Section 2. Three representative fractional-order models often used in bioengineering are described and numerically solved in Section 3. In Section 4 the questions of numerical analysis are discussed. Some conclusion remarks are mentioned in Section 5.
2.1. Fractional Calculus
Fractional calculus is a topic in mathematics that is more than 300 years old. The idea of fractional calculus was suggested early in the development of regular (integer-order) calculus, with the first literature reference being associated with a letter, from Leibniz to L'Hospital in 1695. In this letter the half-order derivative was first mentioned.
2.2. Fractional-Order Systems
There are several possible interpretations of the fractional-order systems. Here are mentioned three of them.
where , , and are the state, input and output vectors of the system and , , , and are the fractional orders. If , system (2.8) is called a commensurate-order system, otherwise it is an incommensurate-order system.
2.3. Discrete Time Approximation of Fractional Calculus: Numerical Method
where is the backward shift operator and is a generating function. This generating function and its expansion determine both the form of the approximation and the coefficients . In this way, the discretization of continuous fractional-order differentiator/integrator can be expressed as . It is known that the forward difference rule is not suitable for applications to causal problems [8, 9].
where and are denoted the gain and phase tuning parameters, respectively, and is sampling period. For example, when and , the generating function (2.13) becomes the forward Euler, the Tustin, the Al-Alaoui, the backward Euler, the implicit Adams rules, respectively. In this sense the generating formula can be tuned more precisely.
The expansion of the generating functions can be done by power series expansion (PSE). It is very important to note that PSE scheme leads to approximations in the form of polynomials of degree , that is, the discretized fractional order derivative is in the form of finite impulse response (FIR) filters, which have only zeros .
where for or for in the relation (2.19). By using a relation (2.14) we obtained a first-order approximation of the fractional derivative of order . Another possibility for the approximation is use, the trapezoidal rule, that is, the use of the generating function (2.13) for and then the PSE, which is convergent of order 2. Other forms of generation functions for higher-order approximation of the fractional order derivative are presented in .
An evaluation of the short memory effect and convergence relation of the error between short and long memory were clearly described and also proved in .
3. Fractional-Order Models in Bioengineering Applications
There are many fractional-order models, which were already used in bioengineering applications as for example [3, 4, 15]: model of neuron, bioelectrode model, model of respiratory mechanics, compartmental model of pharmacokinetics, and so forth, In this section we mention and describe only three of them, namely model of the cells, nuclear magnetic resonance (NMR) model, and Lotka-Volterra (parasite-host or predator-prey) model.
3.1. Fractional-Order Viscoelastic Models of Cells
As we can observe in Figure 1, the numerical solution fits the analytical solution and we can say that both solutions are consistent.
3.2. Fractional-Order Bloch Equations in NMR
In physics and bioengineering, specifically in NMR or magnetic resonance imaging, the Bloch equations are a set of macroscopic equations that are used to calculate the nuclear magnetization as a function of time when relaxation times are (spin-lattice) and (spin-spin). The physical basis for relaxation involves the protons losing their energy to the surrounding lattice, hence the name spin-lattice relaxation. involves the loss of phase coherence between the protons processing in the transverse plane. Different tissues in the body have different values of and . The values depend on the strength of the magnetic field.
Comparison of the proposed numerical solution (3.8) with an analytical solution has been done in  and obtained results show a good consistency of both solutions. In aforementioned work the Matlab function and the Matlab/Simulink model for solution of the fractional-order Bloch equations (3.7) have also been created, which can be widely used for simulations with various parameters , , , and for desired simulation time and initial conditions ( , , ).
Let us consider the following parameters for tissue—gray matter of brain—for a magnetic field strength of 1.5 T from : , , , equilibrium , orders , and , respectively.
We can observe in both figures that fractional orders in the Bloch equations provide expanded model with different behavior for describing a more general NMR, which can find applications in complex materials exhibiting memory.
3.3. Fractional-Order Lotka-Volterra System
where are prey and predator densities, respectively, and all constants , , , , are positive. For and we obtain a well-known model proposed by Alfred Lotka in 1910 and independently by Vito Volterra in 1926.
The stability analysis and numerical solutions of such kind of system have been already studied in . There are two equilibria, when the system (3.9) is solved for and . The above system of equations yields to and if . The stability of the equilibrium point is of importance. If it were stable, nonzero populations might be attracted towards it. However, as the fixed point at the origin is a saddle point, and hence unstable, we find that the extinction of both species is difficult in the model. The second fixed point is not hyperbolic, so no conclusions can be drawn from the linear analysis. However, the system admits a constant of motion and the level curves are closed trajectories surrounding the fixed point. Consequently, the levels of the predator and prey populations cycle and oscillate around this fixed point.
According to knowledge of author, there is no exact analytical solution of the fractional-order Lotka-Volterra equations, which could be compared with the numerical solution. The only possibility is to compare proposed numerical method with an approximate solution obtained via different numerical methods as for example homotopy perturbation method, variational iteration method, and so on.
The proposed numerical method is also known as Euler method which is based on the Grünwald-Letnikov definition of the fractional derivative and can be used for numerical solution of the fractional differential equation even if the fractional-order derivative in differential equation is Caputo's or Riemann-Liouville type. It is based on the fact that for a wide class of functions, all three definitions of the fractional derivatives are equivalent .
Consistency and order. Tell us how well it approximates the solution, we can say, method is consistent if it has an order greater than 0. The method used in this article has order 1 and therefore it is consistent. Order is determined by generating function. Consistency is a necessary condition for convergence, but not sufficient.
- (ii)Convergence. It means whether the method approximates the solution, in other words, a numerical method is said to be convergent if the numerical solution approaches the exact solution as the time step size goes to 0. The method described in this article is convergent because the following condition is satisfied:
for . For instance, we can observe a good result in comparison of exact solution and numerical solution shown in Figure 1. The time step was .
Stability and stiffness. It says whether errors are damped out. For some differential equations, application of standard methods exhibit instability in the solutions, though other methods may produce stable solutions. This behavior in the equation is described as stiffness. Method described in article provides a stable solution.
The numerical method (2.22) proposed for the initial value problem (2.21) holds all three above-mentioned conditions and can be used for solution of linear and nonlinear fractional differential equations. Based on performed experiments, we can consider what is the optimal choice of time step in order to get maximum accuracy in the approximated solution for minimum computational cost. We have used the time steps , , and 0.0005. Numerical solutions show than we may accept the results obtained in this way. The size of the time step also depends on desired relative error in the solution.
In this paper, we presented an effective numerical method and its application to solution of linear and nonlinear models of fractional order used in bioengineering applications. For some of them, Matlab functions [15, 17, 20] were also published. Here, three illustrative examples have been presented as well. It is worth to note that some other methods are also appropriate for solution of such kind of problem, for example predictor-corrector method , Podlubny's matrix approach [21, 22], quadrature formula approach , multistep method , and frequency (Oustaloup's) method , but it has some restrictions, especially for the fractional nonlinear models . In further work, it is necessary to improve this method with proper mathematical analysis and exact determination of the time step size .
This work was supported in part by the Slovak Grant Agency for Science under Grants VEGA: 1/0390/10, 1/0497/11, 1/0746/11, Grants APVV-0040-07 and SK-PL-0052-09.
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